muramic acid | 14599-65-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: muramic acid
• 英文别名: 2-[(3R,4R,5S,6R)-3-amino-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxypropanoic acid
• CAS: 14599-65-6
• 化学式: C₉H₁₇NO₇
• 分子量: 251.236
• InChiKey: MSFSPUZXLOGKHJ-DZCSMQIVSA-N

物化性质

• 沸点：
  572.4±50.0 °C(Predicted)
• 密度：
  1.51±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.6
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  143
• 氢给体数：
  5
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  muramic acid 、 乙酸酐 生成 N-acetylmuramic acid
  参考文献：
  名称：

  KRAUS, RICHARD J.;SHINNICK, FRED L.;MARLETT, JUDITH A., J. CHROMATOGR., 513,(1990) C. 71-81

  摘要：

  DOI：

文献信息

• PRODUCTION OF OLIGOSACCHARIDE MIXTURES BY A CELL
  申请人：Inbiose N.V.

  公开号：EP3954769A1

  公开（公告）日：2022-02-16

  The present invention is in the technical field of synthetic biology and metabolic engineering. More particularly, the present invention is in the technical field of fermentation of metabolically engineered cells. The present invention provides a method for the production of a mixture of at least two different oligosaccharides by a cell as well as the purification of at least one of said oligosaccharides from the cultivation. In addition, the present invention provides a method for the production of a mixture of at least two different oligosaccharides by a metabolically engineered cell as well as the purification of at least one of said oligosaccharides from the cultivation.

  本发明属于合成生物学和代谢工程技术领域。更具体地说，本发明属于代谢工程细胞发酵技术领域。本发明提供了一种细胞生产至少两种不同低聚糖混合物的方法，以及从培养物中纯化至少一种所述低聚糖的方法。此外，本发明还提供了一种通过代谢工程细胞生产至少两种不同低聚糖混合物以及从培养物中纯化至少一种所述低聚糖的方法。
• PRODUCTION OF A MIXTURE OF NEUTRAL NON-FUCOSYLATED OLIGOSACCHARIDES BY A CELL
  申请人：Inbiose N.V.

  公开号：EP3954778A1

  公开（公告）日：2022-02-16

  The present invention is in the technical field of synthetic biology and metabolic engineering. More particularly, the present invention is in the technical field of fermentation of metabolically engineered cells. The present invention describes a metabolically engineered cell for production of a mixture of at least three different neutral non-fucosylated oligosaccharides. Furthermore, the present invention provides a method for the production of a mixture of at least three different neutral non-fucosylated oligosaccharides by a cell as well as the purification of at least one of said oligosaccharides from the cultivation.

  本发明属于合成生物学和代谢工程技术领域。更具体地说，本发明属于代谢工程细胞发酵技术领域。本发明描述了一种用于生产至少三种不同中性非岩藻糖基化低聚糖混合物的代谢工程细胞。此外，本发明还提供了一种细胞生产至少三种不同的中性非琥珀酰化低聚糖混合物的方法，以及从培养物中纯化至少一种所述低聚糖的方法。
• Synthetic N-acetyl-muramic acid derivatives and uses thereof
  申请人：Grimes Catherine Leimkuhler

  公开号：US10988508B2

  公开（公告）日：2021-04-27

  The present invention provides N-acetyl-muramic acid (NAM) derivatives having Formula I, wherein Xa is selected from the group consisting of X1-X59, Ya is selected from the group consisting of H, monophosphate, uridine diphosphate and ethyl azide linker prepared from 2-azido-ethanol, and Za is selected from the group consisting of OH, an ethylene diamine coupled fluorophore, a peptide and a peptide with an ethylene diamine coupled fluorophore, wherein the peptide is selected from the group consisting of a monopeptide, a dipeptide, a tripeptide and a pentapeptide. Also provided are methods for synthesizing NAM derivatives and methods for modulating Nod2 in cells, modifying bacterial cell wall or modulating innate immune response by a subject to bacterial cells upon exposure to NAM derivatives.

  本发明提供了具有式 I 的 N-乙酰基木氨酸（NAM）衍生物，其中 Xa 选自 X1-X59 所组成的组，Ya 选自 H、单磷酸、二磷酸尿苷和由 2-叠氮乙醇制备的乙基叠氮连接体所组成的组、Za选自由OH、乙二胺偶联荧光团、肽和带有乙二胺偶联荧光团的肽组成的组，其中肽选自由单肽、二肽、三肽和五肽组成的组。还提供了合成 NAM 衍生物的方法和用于调节细胞中的 Nod2、调节细菌细胞壁或调节受试者接触 NAM 衍生物后对细菌细胞的先天性免疫反应的方法。
• SYNTHETIC N-ACETYL-MURAMIC ACID DERIVATIVES AND USES THEREOF
  申请人：GRIMES Catherine Leimkuhler

  公开号：US20180298061A1

  公开（公告）日：2018-10-18

  The present invention provides N-acetyl-muramic acid (NAM) derivatives having Formula I, wherein Xa is selected from the group consisting of X1-X59, Ya is selected from the group consisting of H, monophosphate, uridine diphosphate and ethyl azide linker prepared from 2-azido-ethanol, and Za is selected from the group consisting of OH, an ethylene diamine coupled fluorophore, a peptide and a peptide with an ethylene diamine coupled fluorophore, wherein the peptide is selected from the group consisting of a monopeptide, a dipeptide, a tripeptide and a pentapeptide. Also provided are methods for synthesizing NAM derivatives and methods for modulating Nod2 in cells, modifying bacterial cell wall or modulating innate immune response by a subject to bacterial cells upon exposure to NAM derivatives.
• VIABLE BACTERIAL HOST CELL
  申请人：INBIOSE N.V.

  公开号：US20220396761A1

  公开（公告）日：2022-12-15

  The disclosure is in the technical field of synthetic biology and metabolic engineering. The disclosure provides engineered viable bacteria. In particular, the disclosure provides viable bacteria with mutated outer membrane biosynthetic pathway leading to disruption of the pathway, preferably substantially lacking lipopolysaccharide (LPS, endotoxin) within the outer membrane. The disclosure further provides methods of generating viable bacteria and uses thereof. The disclosure also provides compositions and methods for inducing immune responses and for researching and developing therapeutic agents. Furthermore, the disclosure is in the technical field of fermentation of metabolically engineered microorganisms producing bioproduct or metabolite.