methyl Z-4,4-dimethoxy-3-methyl-2-butenoate | 78816-18-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl Z-4,4-dimethoxy-3-methyl-2-butenoate
• 英文别名: methyl (Z)-4,4-dimethoxy-3-methylbut-2-enoate
• CAS: 78816-18-9
• 化学式: C₈H₁₄O₄
• 分子量: 174.197
• InChiKey: XFJWNTZBOUURFO-WAYWQWQTSA-N

物化性质

• 沸点：
  220.9±40.0 °C(Predicted)
• 密度：
  1.021±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.72
• 重原子数：
  12.0
• 可旋转键数：
  4.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  44.76
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  methyl Z-4,4-dimethoxy-3-methyl-2-butenoate 在 10% palladium on active carbon 三氟化硼乙醚 、 氢气 作用下， 以 甲醇 为溶剂， 反应 3.0h， 生成 (2S,4S,5R)-2-((S)-2-Methoxycarbonyl-1-methyl-ethyl)-4-methyl-5-phenyl-oxazolidine-3-carboxylic acid methyl ester
  参考文献：
  名称：

  Asymmetric hydrogenation of 3-methyl-fumaric and maleic ester monoaldehydes protected as neph-derived oxazolidines

  摘要：

  The hydrogenation of 3-methyl-fumaric and maleic ester mono aldehydes protected as oxazolidines of nor-ephedrine (NEPH) derivation has been studied. This transformation takes place with moderate to good pi-face stereodifferentiation and allows the preparation of non-racemic 3-methyl-succinaldehydic acid methyl ester (1, R = Me). The factors dictating the diastereocontrol are discussed.

  DOI：

  10.1016/s0040-4020(01)89738-6
• 作为产物：
  描述：

  t-butyl 4,4-dimethoxy-3-methyl-2-butenoate 在 氢氧化钾 、 四丁基硫酸氢铵 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 12.17h， 生成 methyl Z-4,4-dimethoxy-3-methyl-2-butenoate
  参考文献：
  名称：

  Asymmetric hydrogenation of 3-methyl-fumaric and maleic ester monoaldehydes protected as neph-derived oxazolidines

  摘要：

  The hydrogenation of 3-methyl-fumaric and maleic ester mono aldehydes protected as oxazolidines of nor-ephedrine (NEPH) derivation has been studied. This transformation takes place with moderate to good pi-face stereodifferentiation and allows the preparation of non-racemic 3-methyl-succinaldehydic acid methyl ester (1, R = Me). The factors dictating the diastereocontrol are discussed.

  DOI：

  10.1016/s0040-4020(01)89738-6

文献信息

• Asymmetric induction at C(β) and C(α) of N-enoyl sultams by 1,4-hydride addition/enolate trapping
  作者：Wolfgang Oppolzer、Giovanni Poli

  DOI：10.1016/s0040-4039(00)85046-7

  日期：1986.1

  Conjugate addition of L-Selectride to α, β-enoyl sultams and followed by electrophilic trapping of the resulting enolates gave in one operation saturated imides with high β- and/or α- stereodifferentiation.

  共轭加成三仲丁基硼氢化锂的α，β烯酰基磺内酰胺和接着将得到的烯醇化物的电俘获在具有高β-和/或α-stereodifferentiation一个操作饱和酰亚胺得到。
• Bonadies Francesco, Cardilli Antonella, Lattanzi Alessandra, Orelli Lilia+, Tetrahedron Lett, 35 (1994) N 20, S 3383-3386
  作者：Bonadies Francesco, Cardilli Antonella, Lattanzi Alessandra, Orelli Lilia+

  DOI：——

  日期：——