ethyl N-(6-methyl-1,4-dioxaspiro[4.5]decan-6-yl)carbamate | 1390641-39-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl N-(6-methyl-1,4-dioxaspiro[4.5]decan-6-yl)carbamate
• CAS: 1390641-39-0
• 化学式: C₁₂H₂₁NO₄
• 分子量: 243.303
• InChiKey: QUZCSHHZLJRCAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  6-methyl-1,4-dioxa-spiro[4.5]decane 在 三氟化硼乙醚 、 sodium hydride 作用下， 以 二乙二醇二甲醚 、 1,2-二氯乙烷 、 mineral oil 为溶剂， 反应 84.08h， 生成 ethyl N-(6-methyl-1,4-dioxaspiro[4.5]decan-6-yl)carbamate
  参考文献：
  名称：

  Lewis Acid Catalyzed α-Functionalization of Ketals for the Regioselective Synthesis of α-Carbamoyl Ketals

  摘要：

  Treatment of 1 with DEAD in the presence of BF3 center dot OEt2 gave 2 (R = H), which was N-alkylated to give 2 (R = CH2CO2Et), and insitu eliminated (E1cb) to give alpha-carbamoyl ketals.

  DOI：

  10.1021/ol301710w

文献信息

• Lewis Acid Catalyzed α-Functionalization of Ketals for the Regioselective Synthesis of α-Carbamoyl Ketals
  作者：Philip Magnus、Alec J. Brozell

  DOI：10.1021/ol301710w

  日期：2012.8.3

  Treatment of 1 with DEAD in the presence of BF3 center dot OEt2 gave 2 (R = H), which was N-alkylated to give 2 (R = CH2CO2Et), and insitu eliminated (E1cb) to give alpha-carbamoyl ketals.