3-(trifluoromethyl)-4-((3-(trifluoromethyl)-5-hydroxy-1-(4-methoxyphenyl)-1H-pyrazol-4-yl)(4-nitrophenyl)methyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-ol | 1439908-63-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(trifluoromethyl)-4-((3-(trifluoromethyl)-5-hydroxy-1-(4-methoxyphenyl)-1H-pyrazol-4-yl)(4-nitrophenyl)methyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-ol
• CAS: 1439908-63-0
• 化学式: C₂₉H₂₁F₆N₅O₆
• 分子量: 649.506
• InChiKey: UJRVGLTVASLAMF-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  1‐(4‐methoxyphenyl)‐3‐(trifluoromethyl)‐1H‐pyrazol‐5‐ol 、 对硝基苯甲醛 在 ammonium acetate 作用下， 以 neat (no solvent) 为溶剂， 反应 0.08h， 以92.1%的产率得到3-(trifluoromethyl)-4-((3-(trifluoromethyl)-5-hydroxy-1-(4-methoxyphenyl)-1H-pyrazol-4-yl)(4-nitrophenyl)methyl)-1-(4-methoxyphenyl)-1H-pyrazol-5-ol
  参考文献：
  名称：

  Synthesis and antibacterial activity of 4,4′-(aryl or alkyl methylene)-bis(1H-pyrazol-5-ol) derivatives

  摘要：

  A rapid, improved, and environmentally benign synthesis of 4,4'-aryl or alkyl methylene-bis(1H-pyrazol-5-ols) has been accomplished by tandem Knoevenagel-Michael reaction of 1-aryl-3-alkyl-1H-pyrazol-5-ol with various aldehydes catalyzed by ammonium acetate. All the synthesized compounds 3a-v were evaluated in vitro for their antibacterial activity against Pseudomonas aeruginosa, Xanthomonas protophormiae, Bacillus licheniformis, and Staphylococcus aureus. Among the tested compounds, compounds with trifluromethyl group show excellent antibacterial activity.

  DOI：

  10.1007/s00044-013-0623-3