6(I)-[(2S,4R)-2-carboxypyrrolidin-4-yl]-oxycarbonylamino-6(I)-deoxy-β-cyclodextrin | 1393739-66-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6(I)-[(2S,4R)-2-carboxypyrrolidin-4-yl]-oxycarbonylamino-6(I)-deoxy-β-cyclodextrin
• CAS: 1393739-66-6
• 化学式: C₄₈H₇₈N₂O₃₈
• 分子量: 1291.14
• InChiKey: DHBZVDVMXVNDOS-IGVBUWOGSA-N

反应信息

• 作为产物：
  描述：

  6(I)-[(2S,4R)-1,2-dibenzyloxycarbonylpyrrolidin-4-yl]-oxycarbonylamino-6(I)-deoxy-2(I-VII),3(I-VII),6(II-VII)-eicosakis-obenzyl-β-cyclodextrin 在 palladium on activated charcoal 、 氢气 、 三氟乙酸 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 20.0 ℃ 、310.27 kPa 条件下， 反应 48.0h， 以87%的产率得到6(I)-[(2S,4R)-2-carboxypyrrolidin-4-yl]-oxycarbonylamino-6(I)-deoxy-β-cyclodextrin
  参考文献：
  名称：

  Proline–cyclodextrin conjugates: synthesis and evaluation as catalysts for aldol reaction in water

  摘要：

  The synthesis of six conjugates of L-proline and beta-cyclodextrin and their evaluation as catalysts of aldol reaction in water are described. The results indicated that the nature of the linker between proline and beta-cyclodextrin is important for catalytic activity: the one with the most flexible linker gave the best results. Inhibition experiments showed that the cavity of beta-cyclodextrin plays a role in the catalysis. Permethylation of the cyclodextrin hydroxyl groups led to higher conversion rates. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.06.089