3-Butyloxy-4--chinolin | 571-83-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-Butyloxy-4--chinolin
• 英文别名: 3-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide
• CAS: 571-83-5
• 化学式: C₂₀H₂₉N₃O₂
• 分子量: 343.469
• InChiKey: NRJNDOFWVQZKQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  54.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Method of treating neutrophil-related diseases with topical anesthetics
  申请人：——

  公开号：US20030171402A1

  公开（公告）日：2003-09-11

  A therapeutic method is provided to treat neutrophil-associated pulmonary diseases, such as chronic obstructive pulmonary disease, by locally administering to a mammal in need of such treatment, an effective amount of a topical anesthetic, such as lidocaine, or a pharmaceutically acceptable salt thereof.

  提供了一种治疗方法，通过向需要治疗的哺乳动物局部施用有效量的局部麻醉剂，如利多卡因或其药学上可接受的盐，来治疗中性粒细胞相关的肺部疾病，如慢性阻塞性肺病。
• Neuroprotective benzoate and benzamide compounds
  申请人：Lecanu Laurent

  公开号：US20060167108A1

  公开（公告）日：2006-07-27

  The invention provides a therapeutic method for treating at least one symptom of a neurological disorder or disease such as Alzheimer's disease in a mammal, such as a human, wherein the toxicity of a pathogen of β amyloid peptide and/or glutamate in mammalian cells is implicated and inhibition of the subsequently-induced pathological pathways is desired comprising administering to a mammal in need of such therapy, an effective amount of an N-arylamide or an (N-aminoalkyl)benzamide, including pharmaceutically acceptable salts thereof.

  本发明提供了一种治疗方法，用于治疗哺乳动物（如人类）的神经紊乱或疾病（如阿尔茨海默病）的至少一种症状、其中牵涉到哺乳动物细胞中β淀粉样肽和/或谷氨酸的病原体的毒性，并希望抑制随后诱发的病理途径，包括向需要此类治疗的哺乳动物施用有效量的N-芳酰胺或（N-氨基烷基）苯甲酰胺，包括其药学上可接受的盐。
• USE OF TOPICAL ANESTHETICS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF BRONCHIAL ASTHMA
  申请人：MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH

  公开号：EP0682514B1

  公开（公告）日：2001-09-12
• TREATMENT OF EOSINOPHIL-ASSOCIATED PATHOLOGIES, SUCH AS BRONCHIAL ASTHMA, WITH SYNERGISTIC COMBINATIONS OF GLUCOCORTICOIDS AND A LOCAL ANESTHETICS
  申请人：MAYO FOUNDATION FOR MEDICALEDUCATION AND RESEARCH

  公开号：EP0979085A1

  公开（公告）日：2000-02-16
• METHODS OF TREATING NEUTROPHIL-RELATED DISEASES WITH TOPICAL ANESTHETICS
  申请人：MAYO FOUNDATION FOR MEDICALEDUCATION AND RESEARCH

  公开号：EP1296683A2

  公开（公告）日：2003-04-02