3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-O-(2-phthalimidoethyl)-N⁶-benzoyladenosine | 1037523-20-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-O-(2-phthalimidoethyl)-N⁶-benzoyladenosine
• CAS: 1037523-20-8
• 化学式: C₃₉H₅₀N₆O₈Si₂
• 分子量: 787.032
• InChiKey: WGERJNAXOCMTNY-ZOXBLHLASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.61
• 重原子数：
  55.0
• 可旋转键数：
  11.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.49
• 拓扑面积：
  156.23
• 氢给体数：
  1.0
• 氢受体数：
  12.0

反应信息

• 作为反应物：
  描述：

  3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-O-(2-phthalimidoethyl)-N⁶-benzoyladenosine 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以97%的产率得到2'-O-(2-phthalimidoethyl)-N⁶-benzoyladenosine
  参考文献：
  名称：

  Preparation of Zwitterionic Ribonucleoside Phosphoramidites for Solid-Phase siRNA Synthesis

  摘要：

  RNA oligomers, carrying 2'-O-modified nucleosides, proved to be extremely useful in different antisense strategies, including RNAi. The 2'-O-alkyl modification, carrying an amino functionality, deserves special attention due to its ability to neutralize the negatively charged phosphate backbone, leading to improved physicochemical and pharmaceutical properties of antisense agents. Here, we report a very short, convenient, and straightforward synthesis of phosphoramidites for all four 2'-aminoethyl-modified natural ribonucleosides, where the aminoethyl group is introduced in a single alkylation step.

  DOI：

  10.1021/jo800451m
• 作为产物：
  描述：

  3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-O-(2-phthalimidoethyl)adenosine 、 苯甲酰氯 在 吡啶 作用下， 以66%的产率得到3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-2'-O-(2-phthalimidoethyl)-N⁶-benzoyladenosine
  参考文献：
  名称：

  Preparation of Zwitterionic Ribonucleoside Phosphoramidites for Solid-Phase siRNA Synthesis

  摘要：

  RNA oligomers, carrying 2'-O-modified nucleosides, proved to be extremely useful in different antisense strategies, including RNAi. The 2'-O-alkyl modification, carrying an amino functionality, deserves special attention due to its ability to neutralize the negatively charged phosphate backbone, leading to improved physicochemical and pharmaceutical properties of antisense agents. Here, we report a very short, convenient, and straightforward synthesis of phosphoramidites for all four 2'-aminoethyl-modified natural ribonucleosides, where the aminoethyl group is introduced in a single alkylation step.

  DOI：

  10.1021/jo800451m