5'-benzoyl-2',3'-di-O-acetyl-guanosine | 1024591-78-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 5'-benzoyl-2',3'-di-O-acetyl-guanosine
• 英文别名: [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(2-amino-6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl benzoate
• CAS: 1024591-78-3
• 化学式: C₂₁H₂₁N₅O₈
• 分子量: 471.426
• InChiKey: WRUNEOPWXBVSPS-NVQRDWNXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  173
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• COMPOUND HAVING INHIBITORY ACTIVITY ON A RHO-GTPASE CELL PROTEIN, A PROCESS FOR OBTAINING THE SAME, PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF AND A METHOD FOR THE TREATMENT OF RHO-GTPASE CELL PROTEIN-MEDIATED CONDITION
  申请人：Alonso Daniel Fernando

  公开号：US20090324708A1

  公开（公告）日：2009-12-31

  The present invention relates to a compound having inhibitory activity on a Rho-GTPase cell protein, the compound having the formula I (Formula I) wherein A is selected from N and N—H, R 1 is selected from H and NHR 3 , R 2 is selected from NHR 4 , OR 4 , O and halogen, R 3 is selected from H and —COR 5 , R 4 is selected from H, a C 1 -C 6 alkyl and a substituted or unsubstituted phenyl, R 5 is selected from a C 1 -C 12 alkyl and a substituted or unsubstituted phenyl, R 6 is selected from H, —COR 5 , —CO 2 R 5 , —PR 7 R 8 and —PR 7 R 8 OPR 7 R 8 R 8 R 7 , R 7 is selected from O and S, R 8 is selected from H, OR 4 and OSATE (—OCH 2 CH 2 SCOR 5 ), and wherein each represents a single bond or a double bond, provided that when one of them is a double bond the other one is a single bond, and pharmaceutically acceptable salts and derivatives thereof. In particular, the compounds of the invention may be used as antitumor agents the action of which interfere with the signaling pathways normally involved in tumor development processes. The invention also relates to processes for obtaining of compounds having inhibitory activity of a Rho-GTPase cell protein, to the pharmaceutical compositions thereof and to the therapeutic methods comprising the use of said compounds and compositions.