2-(4-Methoxyphenyl)sulfonyl-4-phenyltriazole | 1209494-85-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-Methoxyphenyl)sulfonyl-4-phenyltriazole
• 英文别名: 2-(4-methoxyphenyl)sulfonyl-4-phenyltriazole
• CAS: 1209494-85-8
• 化学式: C₁₅H₁₃N₃O₃S
• 分子量: 315.353
• InChiKey: AOYSUAAHBQRUKT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  82.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-((4-methoxyphenyl)sulfonyl)-4-phenyl-1H-1,2,3-triazole 在 4-二甲氨基吡啶 、 溶剂黄146 作用下， 以 乙腈 、 水 为溶剂， 以73%的产率得到2-(4-Methoxyphenyl)sulfonyl-4-phenyltriazole
  参考文献：
  名称：

  Preparation of 2-Sulfonyl-1,2,3-triazoles by Base-Promoted 1,2-Rearrangement of a Sulfonyl Group

  摘要：

  1,2-Rearrangement of a sulfonyl group occurs on treatment of 1-sulfony1-1,2,3-triazoles with a catalytic amount of 4-dimethylaminopyridine (DMAP) in acetonitrile to give an equilibrium mixture of 1-sulfonyl- and 2-sulfonyl derivatives, with considerable predominance of the latter. Subsequent acidic treatment of the mixture caused selective hydrolysis of the 1-sulfonyl derivative, which led to the isolation of the 2-sulfony1-1,2,3-triazole in good total yield in a pure form.

  DOI：

  10.3987/com-09-s(s)44

文献信息

• Preparation of 2-Sulfonyl-1,2,3-triazoles by Base-Promoted 1,2-Rearrangement of a Sulfonyl Group
  作者：Masahiro Murakami、Motoshi Yamauchi、Tomoya Miura

  DOI：10.3987/com-09-s(s)44

  日期：——

  1,2-Rearrangement of a sulfonyl group occurs on treatment of 1-sulfony1-1,2,3-triazoles with a catalytic amount of 4-dimethylaminopyridine (DMAP) in acetonitrile to give an equilibrium mixture of 1-sulfonyl- and 2-sulfonyl derivatives, with considerable predominance of the latter. Subsequent acidic treatment of the mixture caused selective hydrolysis of the 1-sulfonyl derivative, which led to the isolation of the 2-sulfony1-1,2,3-triazole in good total yield in a pure form.