N-[[amino-(9-phenylpurin-6-yl)methylidene]amino]acetamide | 1628817-27-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[[amino-(9-phenylpurin-6-yl)methylidene]amino]acetamide
• CAS: 1628817-27-5
• 化学式: C₁₄H₁₃N₇O
• 分子量: 295.304
• InChiKey: AONOBHOKQVRTFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  111
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N-[[amino-(9-phenylpurin-6-yl)methylidene]amino]acetamide 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以63%的产率得到N'-(8-anilinopyrimido[5,4-d]pyrimidin-4-yl)acetohydrazide
  参考文献：
  名称：

  6-Carbohydrazonamidepurines: Convenient Precursors for 4,8-Disubstituted Pyrimido[5,4-d]pyrimidines

  摘要：

  A series of 4-arylamino-8-(alkyl or aryl)hydrazidepyrimido[5,4-d]pyrimidines was obtained efficiently from 6-carbohydrazonamidepurines by reaction with piperidine. The 6-carbo-hydrazonamidepurines were generated selectively by the reaction of 6-imidatopurine with hydrazides under acidic conditions.

  DOI：

  10.1055/s-0033-1340344
• 作为产物：
  描述：

  Methyl 9-phenylpurine-6-carboximidate 、 乙酰肼 在 硫酸 作用下， 以 二甲基亚砜 为溶剂， 反应 1.0h， 以51%的产率得到N-[[amino-(9-phenylpurin-6-yl)methylidene]amino]acetamide
  参考文献：
  名称：

  6-Carbohydrazonamidepurines: Convenient Precursors for 4,8-Disubstituted Pyrimido[5,4-d]pyrimidines

  摘要：

  A series of 4-arylamino-8-(alkyl or aryl)hydrazidepyrimido[5,4-d]pyrimidines was obtained efficiently from 6-carbohydrazonamidepurines by reaction with piperidine. The 6-carbo-hydrazonamidepurines were generated selectively by the reaction of 6-imidatopurine with hydrazides under acidic conditions.

  DOI：

  10.1055/s-0033-1340344

文献信息

• 6-Carbohydrazonamidepurines: Convenient Precursors for 4,8-Disubstituted Pyrimido[5,4-d]pyrimidines
  作者：M. Carvalho、Ashly Rocha、Ana Bacelar、Joana Fernandes、M. Proenca

  DOI：10.1055/s-0033-1340344

  日期：——

  A series of 4-arylamino-8-(alkyl or aryl)hydrazidepyrimido[5,4-d]pyrimidines was obtained efficiently from 6-carbohydrazonamidepurines by reaction with piperidine. The 6-carbo-hydrazonamidepurines were generated selectively by the reaction of 6-imidatopurine with hydrazides under acidic conditions.