8-Bromo-2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-ol | 1560759-08-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 8-Bromo-2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-ol
• 英文别名: 8-bromo-2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-ol
• CAS: 1560759-08-1
• 化学式: C₁₄H₁₁BrN₂O₂
• 分子量: 319.158
• InChiKey: OYMYFPBCOPYANA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  46.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基-3-溴吡啶 、 4-甲氧基苯硼酸 、 乙醛酸 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.5h， 以40%的产率得到8-Bromo-2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-ol
  参考文献：
  名称：

  An expeditious approach to access 2-arylimidazo[1,2-a]pyridin-3-ol from 2-amino pyridine through a novel Petasis based cascade reaction

  摘要：

  An expeditious cascade protocol for the synthesis of functionalized imidazo[1,2-a]pyridin-3-ols was developed based on the Petasis reaction. With the availability of commercial reagents and high efficiency in expanding molecule diversity, this methodology is superior to the existing procedures for the synthesis of imidazo-pyridin-3-ol analogues. (C) 2014 Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2013.12.018

文献信息

• An expeditious approach to access 2-arylimidazo[1,2-a]pyridin-3-ol from 2-amino pyridine through a novel Petasis based cascade reaction
  作者：Yuanxiang Wang、Biswajit Saha、Fang Li、Brendan Frett、Hong-yu Li

  DOI：10.1016/j.tetlet.2013.12.018

  日期：2014.2

  An expeditious cascade protocol for the synthesis of functionalized imidazo[1,2-a]pyridin-3-ols was developed based on the Petasis reaction. With the availability of commercial reagents and high efficiency in expanding molecule diversity, this methodology is superior to the existing procedures for the synthesis of imidazo-pyridin-3-ol analogues. (C) 2014 Published by Elsevier Ltd.