7-[(acetoacetyl)(tetrahydro-2-furanylmethyl)amino]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | 341005-16-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-[(acetoacetyl)(tetrahydro-2-furanylmethyl)amino]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
• 英文别名: 1-Cyclopropyl-6-fluoro-4-oxo-7-[3-oxobutanoyl(oxolan-2-ylmethyl)amino]quinoline-3-carboxylic acid
• CAS: 341005-16-1
• 化学式: C₂₂H₂₃FN₂O₆
• 分子量: 430.433
• InChiKey: RCWLHSOCYNQOCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  104
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Thio-oxindole derivatives
  申请人：WYETH

  公开号：US20020169198A1

  公开（公告）日：2002-11-14

  This invention relates to methods of co-administering compounds of formula 1 which are agonists of the progesterone receptor which have the general structure: 1 wherein: R 1 , R 2 , R 3 , R 4 , R 5 and Q 1 are as defined herein, or a pharmaceutically acceptable salt thereof, with estrogen, an estrogen, or an estrogen receptor agonist for contraception, hormone replacement therapy, or treating progesterone-related carcinomas and adenocarcinomas.

  本发明涉及一种联合使用公式1化合物的方法，该化合物是孕激素受体的激动剂，具有以下一般结构：1其中：R1、R2、R3、R4、R5和Q1如此定义，或其药学上可接受的盐，与雌激素、雌激素或雌激素受体激动剂联合使用，用于避孕、激素替代治疗或治疗孕激素相关的癌症和腺癌。
• COMPOUNDS WITH ANTIBACTERIAL AND ANTIPARASITIC PROPERTIES
  申请人：New Pharma Research Sweden AB

  公开号：EP1230235B1

  公开（公告）日：2008-06-11
• Methods of Treating Hormone-Related Conditions Using Thio-Oxindole Derivatives
  申请人：Fensome Andrew

  公开号：US20120220558A1

  公开（公告）日：2012-08-30

  The present invention provides methods of inducing contraception which includes delivering to a female a composition containing a compound of formula I, or tautomers thereof, in a regimen which involves delivering one or more of a selective estrogen receptor modulator, wherein formula I is: and wherein R 1 -R 5 and Q 1 are defined as described herein. Methods of providing hormone replacement therapy and for treating carcinomas, dysfunctional bleeding, uterine leiomyomata, endometriosis, and polycystic ovary syndrome is provided which includes delivering a compound of formula I and a selective estrogen receptor modulator are also described.
• US6946454B2
  申请人：——

  公开号：US6946454B2

  公开（公告）日：2005-09-20
• US6967205B1
  申请人：——

  公开号：US6967205B1

  公开（公告）日：2005-11-22