ethyl 3,6-di-O-benzyl-4-O-(2,3,6-tri-O-benzyl-α-D-glucopyranosyl)-2-deoxy-1-thio-β-D-arabino-hexopyranoside | 1119276-04-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl 3,6-di-O-benzyl-4-O-(2,3,6-tri-O-benzyl-α-D-glucopyranosyl)-2-deoxy-1-thio-β-D-arabino-hexopyranoside
• 英文别名: Bn(-2)[Bn(-3)][Bn(-6)]Glc(a1-4)[Bn(-3)][Bn(-6)]2-deoxy-D-araHex(b)-SEt；(2R,3R,4S,5R,6R)-6-[(2R,3S,4R,6S)-6-ethylsulfanyl-4-phenylmethoxy-2-(phenylmethoxymethyl)oxan-3-yl]oxy-4,5-bis(phenylmethoxy)-2-(phenylmethoxymethyl)oxan-3-ol
• CAS: 1119276-04-8
• 化学式: C₄₉H₅₆O₉S
• 分子量: 821.044
• InChiKey: RJUXCSCNGWABMO-MGHBDOBZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  59
• 可旋转键数：
  21
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  119
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  ethyl 3,6-di-O-benzyl-4-O-(2,3,6-tri-O-benzyl-α-D-glucopyranosyl)-2-deoxy-1-thio-β-D-arabino-hexopyranoside 在 N-碘代丁二酰亚胺 、 silver trifluoromethanesulfonate 作用下， 以 二氯甲烷 为溶剂， 反应 12.0h， 以75%的产率得到Bn(-2)[Bn(-3)][Bn(-6)]Glc(a1-4)[Bn(-3)][Bn(-6)]2-deoxy-D-araHex
  参考文献：
  名称：

  Synthesis of 2-deoxy cyclic and linear oligosaccharides by oligomerization of monomers

  摘要：

  Cyclic and linear oligosaccharides constituted with 2-deoxy sugar units are synthesized by an oligomerization reaction involving activated thioglycoside monomers, consisting of a 2-deoxy sugar unit. The oligomerization promoter plays an important role in the formation of either the cyclic- or the linear oligosaccharides. Encapsulation abilities of a 2-deoxy cyclic hexamer with p-nitrophenot, by a H-1 NMR method, showed complexation of the guest molecule with the host molecule. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2008.10.026
• 作为产物：
  描述：

  ethyl 3,6-di-O-benzyl-4-O-(2,3-di-O-benzyl-α-D-glucopyranosyl)-2-deoxy-1-thio-β-D-arabino-hexopyranoside 、 溴甲苯 在 二正丁基氧化锡 、 四丁基溴化铵 作用下， 以 甲苯 为溶剂， 反应 20.0h， 以80%的产率得到ethyl 3,6-di-O-benzyl-4-O-(2,3,6-tri-O-benzyl-α-D-glucopyranosyl)-2-deoxy-1-thio-β-D-arabino-hexopyranoside
  参考文献：
  名称：

  Synthesis of 2-deoxy cyclic and linear oligosaccharides by oligomerization of monomers

  摘要：

  Cyclic and linear oligosaccharides constituted with 2-deoxy sugar units are synthesized by an oligomerization reaction involving activated thioglycoside monomers, consisting of a 2-deoxy sugar unit. The oligomerization promoter plays an important role in the formation of either the cyclic- or the linear oligosaccharides. Encapsulation abilities of a 2-deoxy cyclic hexamer with p-nitrophenot, by a H-1 NMR method, showed complexation of the guest molecule with the host molecule. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2008.10.026

文献信息

• Synthesis of 2-deoxy cyclic and linear oligosaccharides by oligomerization of monomers
  作者：Somak Paul、Srinivasarao Raghothama、Narayanaswamy Jayaraman

  DOI：10.1016/j.carres.2008.10.026

  日期：2009.1

  Cyclic and linear oligosaccharides constituted with 2-deoxy sugar units are synthesized by an oligomerization reaction involving activated thioglycoside monomers, consisting of a 2-deoxy sugar unit. The oligomerization promoter plays an important role in the formation of either the cyclic- or the linear oligosaccharides. Encapsulation abilities of a 2-deoxy cyclic hexamer with p-nitrophenot, by a H-1 NMR method, showed complexation of the guest molecule with the host molecule. (C) 2008 Elsevier Ltd. All rights reserved.