4-(3,5-二甲基苯基)吡啶 | 1214379-51-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 4-(3,5-二甲基苯基)吡啶
• 英文名称: 4-(3,5-dimethylphenyl)pyridine
• CAS: 1214379-51-7
• 化学式: C₁₃H₁₃N
• 分子量: 183.253
• InChiKey: OLICYLQISCRVIM-UHFFFAOYSA-N

物化性质

• 沸点：
  285.1±9.0 °C(Predicted)
• 密度：
  1.015±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(3,5-二甲基苯基)吡啶 在 platinum(IV) oxide 、 氢气 、 甲烷 、 三氟乙酸 作用下， 以 甲醇 为溶剂， 20.0 ℃ 、1.0 MPa 条件下， 以99 %的产率得到4-(3,5-dimethylphenyl)piperidine
  参考文献：
  名称：

  10.1021/jacs.4c05883

  摘要：

  DOI：

  10.1021/jacs.4c05883
• 作为产物：
  描述：

  4-溴吡啶 、 3,5-二甲基苯硼酸 在 sodium carbonate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以99%的产率得到4-(3,5-二甲基苯基)吡啶
  参考文献：
  名称：

  Dynamic functionalised metallogel: An approach to immobilised catalysis with improved activity

  摘要：

  A metal-organic gel (MOG) route to immobilised catalysts has been developed based on the reversibility of coordination bond formation in a Fe3+-carboxylate MOG. The ferric gel was rationally designed based on a bifunctional ligand, 5-1H-benzo[d]imidazole-1,3-dicarboxylic acid (L1), in which the imidazole N atom may further hind to a soft ion like Pd2+ more strongly Clue to the HSAB matching. Palladium(II) was successfully loaded in the gel to yield a supported coordination catalyst. Compared with its homogeneous counterparts, the immobilised gel catalyst exhibited significantly improved catalytic activity Under mild conditions as shown in Suzuki-Miyaura C-C coupling, and Could be reused for several times. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2009.11.001

文献信息

• [EN] SUBSTITUTED INDOLE MCL-1 INHIBITORS<br/>[FR] INHIBITEURS DE INDOLE MCL-1 SUBSTITUÉS
  申请人：UNIV VANDERBILT

  公开号：WO2015148854A1

  公开（公告）日：2015-10-01

  The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.

  本发明提供了一种抑制抗凋亡Bcl-2家族成员髓细胞白血病-1 (Mcl-1)蛋白活性的化合物。本发明还提供了用于治疗因Mcl-1蛋白过度表达或失调而表征的疾病和病况（例如癌症）的药物组合物以及使用化合物的方法。
• Palladium dichloride adduct of N,N-bis-(diphenylphosphanylmethyl)-2-aminopyridine: synthesis, structure and catalytic performance in the decarboxylative cross-coupling of 4-picolinic acid with aryl bromide
  作者：Run-Tian He、Jian-Feng Wang、Hui-Fang Wang、Zhi-Gang Ren、Jian-Ping Lang

  DOI：10.1039/c4dt00815d

  日期：——

  Reaction of PdCl2 with N,N-bis-(diphenylphosphanylmethyl)-2-aminopyridine (bdppmapy) afforded a mononuclear complex [(bdppmapy)PdCl2] (1). Compound 1 was characterized by elemental analysis, IR, 1H, 13C and 31P NMR, electrospray ion mass spectra (ESI-MS) and X-ray single crystal crystallography. The Pd(II) center in 1 is chelated by bdppmapy, showing a cis-square planar geometry. With the assistance of additive Cu2O, complex 1 exhibited good catalytic activity toward the decarboxylative cross-coupling reactions between 4-picolinic acid and aryl bromides. In the presence of only 2 mol% catalyst, a family of 4-aryl-pyridines could be isolated in up to 83% yield.

  PdCl2与N,N-bis-(diphenylphosphanylmethyl)-2-aminopyridine (bdppmapy)反应生成单核配合物[(bdppmapy)PdCl2] (1)。化合物1通过元素分析、红外光谱、1H、13C和31P NMR、电喷雾离子质谱（ESI-MS）以及X射线单晶晶体学进行了表征。1中Pd(II)中心被bdppmapy咬合，显示出顺式正方平面几何结构。在添加剂Cu2O的辅助下，配合物1在4-吡啶酸与芳基溴化物之间的去羧交叉偶联反应中表现出良好的催化活性。在仅使用2摩尔%的催化剂的情况下，能够分离出一系列4-芳基吡啶，产率高达83%。
• Chromophoric Lewis Base Adducts of Methyltrioxorhenium: Synthesis, Catalysis and Photochemistry
  作者：Simone A. Hauser、Valentina Korinth、Eberhardt Herdtweck、Mirza Cokoja、Wolfgang A. Herrmann、Fritz E. Kühn

  DOI：10.1002/ejic.201000348

  日期：2010.9

  A series of chromophoric Lewis base adducts of methyltrioxorhenium (MTO) was examined. The ligands were pyridine derivatives with different size of the aromatic system and variable substituents, thus providing a variation of electronic and steric parameters. The complexes were fully characterised (UV/Vis, IR and NMR spectroscopy, single-crystal X-ray diffraction and elemental analysis) and their stability

  研究了一系列甲基三氧铼 (MTO) 的发色路易斯碱加合物。配体是具有不同大小的芳香系统和可变取代基的吡啶衍生物，因此提供了电子和空间参数的变化。对配合物进行了充分表征（UV/Vis、IR 和 NMR 光谱、单晶 X 射线衍射和元素分析），并通过 UV/Vis 光谱测定了它们在二氯甲烷中的稳定性常数。此外，本报告还研究了与 MTO 配位的这些 N-供体配体对 1-辛烯环氧化催化活性的影响。每个化合物测试两次；在避光和日光下进行催化反应。未发现催化性能有显着差异。通过 (17)O-NMR 和 UV/Vis 光谱研究了配合物在紫外光照射下的行为。本文公开的实验旨在探讨 MTO 加合物中发色 N 供体配体的潜在有益作用，因为它们可能通过提供额外的能量来削弱在催化循环中必须断裂的键来激活催化系统。
• CONDENSED CYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME
  申请人：SAMSUNG DISPLAY CO., LTD.

  公开号：US20170077422A1

  公开（公告）日：2017-03-16

  An organic light-emitting device includes: a first electrode; a second electrode facing the first electrode; and an organic layer between the first electrode and the second electrode, the organic layer including an emission layer, wherein the organic layer includes at least one condensed cyclic compound of Formula 1: An organic light-emitting device including the condensed cyclic compound according to embodiments of the present disclosure may have low driving voltage, high efficiency, high luminance, and long lifespan.

  一种有机发光器件包括：第一电极；面向第一电极的第二电极；以及位于第一电极和第二电极之间的有机层，该有机层包括一个发射层，其中，该有机层包括至少一个公式1的缩合环化合物：根据本公开的实施例所述的包括缩合环化合物的有机发光器件可能具有低驱动电压、高效率、高亮度和长寿命。
• SUBSTITUTED INDOLE MCL-1 INHIBITORS
  申请人：Vanderbilt University

  公开号：US20170174689A1

  公开（公告）日：2017-06-22

  The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.

  本发明提供了一种抑制抗凋亡Bcl-2家族成员髓性细胞白血病-1（Mcl-1）蛋白活性的化合物。本发明还提供了药物组合物以及使用化合物治疗由于Mcl-1蛋白过度表达或失调而导致的疾病和病况（例如癌症）的方法。