4-formyl-2-methoxyphenyl (2E)-3-(3,4-dihydroxyphenyl)acrylate | 1029519-22-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 4-formyl-2-methoxyphenyl (2E)-3-(3,4-dihydroxyphenyl)acrylate
• 英文别名: (e)-4-Formyl-2-methoxyphenyl 3-(3,4-dihydroxyphenyl)acrylate；(4-formyl-2-methoxyphenyl) (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
• CAS: 1029519-22-9
• 化学式: C₁₇H₁₄O₆
• 分子量: 314.295
• InChiKey: KAWOJURGCHLPIU-QPJJXVBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• NOVEL CHEMOTHERAPEUTIC AGENTS AGAINST INFLAMMATION AND CANCER
  申请人：Bose Julie Saha

  公开号：US20100168228A1

  公开（公告）日：2010-07-01

  Novel compounds, their methods of preparation and use in therapies related to cancer and inflammation are provided. Compounds comprise esters of cinnamic acid, vanillic acid and 4-hydroxy cinnamic acid and derivatives and salts thereof. Compounds with novel benzofuran lignan structure as a potent antimitotic agent and inducer of apoptosis are provided. Formulations and methods for treatment of diseases mediated by NF-kappaB are also provided.

  提供了新型化合物、其制备方法以及在与癌症和炎症相关的治疗中的用途。这些化合物包括肉桂酸酯、香草酸酯和4-羟基肉桂酸酯及其衍生物和盐。提供了具有新型苯并呋喃木脂素结构的化合物，作为一种强效抗有丝分裂剂和诱导凋亡剂。还提供了用于治疗NF-kappaB介导的疾病的配方和方法。
• [EN] MULTIFUNCTIONAL CAFFEIC ACID O-METHYLTRANSFERASE<br/>[FR] O-METHYLTRANSFERASE D'ACIDE CAFEIQUE MULTIFONCTIONNELLE
  申请人：BAYERISCHE JULIUS MAXIMILIANS

  公开号：WO2003046163A2

  公开（公告）日：2003-06-05

  The present invention is related to an isolated polypeptide capable of methylating an ortho-dihydroxy substituted ring system, whereby the ring system preferably is an aromatic, or heteroaromatic ring system or furanone based ring, and mimetics of said ortho-dihydroxy substituted ring system, selected from the group consisting of: (a) a polypeptide having an amino acid sequence which has at least 65% identity with amino acids 1 to 365 for the mature polypeptide of SEQ ID NO. 2; (b) a polypeptide which is encoded by a nucleic acid sequence which hybridizes under high stringency conditions with (i) the open reading frame coding for SEQ ID No 2 within the nucleotide sequence SEQ ID No. 1, (ii) a subsequence of (i) of at least 100 nucleotides, preferably of at least 100 consecutive nucleotides, or (iii) a complementary strand of (i), or (ii); (c) a polypeptide which is encoded by a nucleic acid having a nucleic acid sequence according to SEQ. ID. No. 1 or SEQ. ID. No. 3; (d) an allelic variant of (a), (b), or (c) and (e) a fragment of (a), (b), (c) or (d) that has methyltransferase activity using as a substrate an ortho-dihydroxy substituted ring system or a mimetic thereof.
• [EN] NOVEL CHEMOTHERAPEUTIC AGENTS AGAINST INFLAMMATION AND CANCER<br/>[FR] NOUVEAUX AGENTS CHIMIOTHÉRAPEUTIQUES CONTRE L'INFLAMMATION ET LE CANCER
  申请人：RELIANCE LIFE SCIENCES PVT LTD

  公开号：WO2008062466A2

  公开（公告）日：2008-05-29

  [EN] Novel compounds, their methods of preparation and use in therapies related to cancer and inflammation are provided. Compounds comprise esters of cinnamic acid, vanillic acid and 4- hyrdoxy cinnamic acid and derivatives and salts thereof. Compounds with novel benzofuran lignan structure as a potent antimitotic agent and inducer of apoptosis are provided. Formulations and methods for treatment of diseases mediated by NF-kappaB are also provided.
  [FR] L'invention concerne de nouveaux composés, leurs procédés de préparation et leur utilisation dans des traitements associés au cancer et à l'inflammation. Lesdits composés comprennent des esters d'acide cinnamique, d'acide vanillique et d'acide 4-hydroxy-cinnamique ainsi que des dérivés et des sels correspondants. L'invention concerne également des composés présentant une nouvelle structure benzofurane lignane, utilisés comme puissant agent antimitotique et comme puissant inducteur de l'apoptose. L'invention se rapporte en outre à des préparations et des méthodes de traitement de maladies médiées par le NF-kappaB.