(5R,7S,8R)-N-hydroxy-8-({4-[(2-methyl-4-quinolinyl)methoxy]benzoyl}amino)-1-oxaspiro[4.4]nonane-7-carboxamide trifluoroacetate | 461664-58-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (5R,7S,8R)-N-hydroxy-8-({4-[(2-methyl-4-quinolinyl)methoxy]benzoyl}amino)-1-oxaspiro[4.4]nonane-7-carboxamide trifluoroacetate
• 英文别名: (5R,7S,8R)-N-hydroxy-8-[[4-[(2-methylquinolin-4-yl)methoxy]benzoyl]amino]-1-oxaspiro[4.4]nonane-7-carboxamide;2,2,2-trifluoroacetic acid
• CAS: 461664-58-4
• 化学式: C₂HF₃O₂*C₂₇H₂₉N₃O₅
• 分子量: 589.568
• InChiKey: OELXTMYRXBNTEA-JOMOBAHMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.32
• 重原子数：
  42
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  147
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• Spiro-cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha converting enzyme (TACE)
  申请人：——

  公开号：US20030087882A1

  公开（公告）日：2003-05-08

  The present application describes novel spiro-cyclic &bgr;-amino acid derivatives of formula I: 1 or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms a 3-11 membered spiro-carbocycle or spiro-heterocycleon ring B, and the other variables are defined in the present specification, which are useful as as matrix metalloproteinases (MMP), TNF-&agr; converting enzyme (TACE), and/or aggrecanase inhibitors.

  本申请描述了新颖的式I的螺环式&bgr;-氨基酸衍生物或其药用盐形式，其中环B是3-13成员碳环或杂环，环C形成3-11成员的螺环碳环或螺环杂环在环B上，并且其他变量在本规范中定义，这些衍生物可用作基质金属蛋白酶（MMP）、TNF-&agr;转化酶（TACE）和/或聚集素酶抑制剂。
• Assay for detecting methylation status by methylation specific primer extension (MSPE)
  申请人：Li Zheng

  公开号：US20050214812A1

  公开（公告）日：2005-09-29

  The present invention relates to detecting the relative methylation levels at one or more CpG sites on a nucleic acid molecule, by using the methylation specific primer extension reaction (MSPE). MSPE uses an agent to modify unmethylated cytosine at a CpG site to uracil and subsequently amplify the chemically treated nucleic acids. The MSPE primers distinguishing between unmethylated and methylated CpG sites are provided to conduct MSPE. Relative methylation levels at one or more CpG sites are performed by detecting the signal intensity of labels incorporated into the MSPE reaction products.

  本发明涉及利用甲基化特异性引物延伸反应（MSPE）检测核酸分子上一个或多个 CpG 位点的相对甲基化水平。MSPE 使用一种药剂将 CpG 位点上未甲基化的胞嘧啶修饰成尿嘧啶，然后扩增经化学处理的核酸。为进行 MSPE，提供了区分未甲基化和甲基化 CpG 位点的 MSPE 引物。一个或多个 CpG 位点的相对甲基化水平是通过检测加入到 MSPE 反应产物中的标签的信号强度来实现的。
• US6720329B2
  申请人：——

  公开号：US6720329B2

  公开（公告）日：2004-04-13
• US6962938B2
  申请人：——

  公开号：US6962938B2

  公开（公告）日：2005-11-08