11-Chloro-15-oxa-18-azatetracyclo[8.8.0.02,7.012,17]octadeca-1(10),2,4,6,8,11,17-heptaen-16-one | 1015474-12-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 11-Chloro-15-oxa-18-azatetracyclo[8.8.0.02,7.012,17]octadeca-1(10),2,4,6,8,11,17-heptaen-16-one
• 英文别名: 11-chloro-15-oxa-18-azatetracyclo[8.8.0.02,7.012,17]octadeca-1(10),2,4,6,8,11,17-heptaen-16-one
• CAS: 1015474-12-0
• 化学式: C₁₆H₁₀ClNO₂
• 分子量: 283.714
• InChiKey: OEAWEFOGBDXPRD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-chloro-3-(2-chloro-ethyl)-2-methyl-benzo[h]quinoline 在 selenium(IV) oxide 作用下， 以 吡啶 为溶剂， 以55%的产率得到11-Chloro-15-oxa-18-azatetracyclo[8.8.0.02,7.012,17]octadeca-1(10),2,4,6,8,11,17-heptaen-16-one
  参考文献：
  名称：

  An efficient route to a 5,6-dihydropyrano[3,4-b]pyridin-8-one core in two steps from enaminolactones

  摘要：

  A convenient two step conversion of heterocyclic enaminolactones to heterocyclic fused 2-pyran-1-ones is reported. The use of this method can be applied to a wide variety of aromatic and heteroaromatic amines to give potentially biologically active compounds in good yields. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.12.106

文献信息

• An efficient route to a 5,6-dihydropyrano[3,4-b]pyridin-8-one core in two steps from enaminolactones
  作者：Cheikh Sall、Nicolas Desbois、Sandrine Paquelet、José R. Camacho、Jean Michel Chezal、Jean-Claude Teulade、Yves Blache

  DOI：10.1016/j.tetlet.2007.12.106

  日期：2008.2

  A convenient two step conversion of heterocyclic enaminolactones to heterocyclic fused 2-pyran-1-ones is reported. The use of this method can be applied to a wide variety of aromatic and heteroaromatic amines to give potentially biologically active compounds in good yields. (c) 2007 Elsevier Ltd. All rights reserved.