7α-benzyloxymethyl-6β-indol-3'-yl-9α-methyl-5,6α,6aβ,7β,8,9β,10,10aβ-octahydroindeno<2,1-b>indole | 142502-07-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 7α-benzyloxymethyl-6β-indol-3'-yl-9α-methyl-5,6α,6aβ,7β,8,9β,10,10aβ-octahydroindeno<2,1-b>indole
• 英文别名: (6S,6aS,7S,9S,10aR)-6-(1H-indol-3-yl)-9-methyl-7-(phenylmethoxymethyl)-5,6,6a,7,8,9,10,10a-octahydroindeno[2,1-b]indole
• CAS: 142502-07-6
• 化学式: C₃₂H₃₂N₂O
• 分子量: 460.619
• InChiKey: OWBOQTBBWRAYCS-CZLGHUJXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  35
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  40.8
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  6α-hydroxy-7α-hydroxymethyl-9α-methyl-5-tosyl-5,6β,6aβ,7β,8,9β,10,10aβ-octahydroindeno<2,1-b>indole 在 4-二甲氨基吡啶 、 sodium hydroxide 、 disodium hydrogenphosphate 、 sodium amalgam 、 四丁基硫酸氢铵 、 三乙胺 作用下， 以 甲醇 、 乙醚 、 氯仿 、 苯 为溶剂， 反应 3.0h， 生成 7α-benzyloxymethyl-6β-indol-3'-yl-9α-methyl-5,6α,6aβ,7β,8,9β,10,10aβ-octahydroindeno<2,1-b>indole
  参考文献：
  名称：

  Structure-function relationship of Yuehchukene II. The effect of C-6 indole rotation on anti-implantation activity

  摘要：

  In a first attempts to define the structural requirements for the expression of anti-implantation activity in Yuehchukene (YCK), it was found that the relative position or planarity of the aromatic centres may be crucial. New synthetic routes leading to analogues with modification of C-7 substituents were established. Results indicated that a bulky group at C-7 that served to restrict the rotation of the C-6 indole was indispensable. Further steric hindrance by 2'-methyl would increase potency in all weak analogues. It was concluded that YCK required an optimal conformation that was defined by a narrowly-fixed angle between the, planes of the C-6 indole and the tetracyclic unit.

  DOI：

  10.1016/0223-5234(92)90100-f

文献信息

• Structure-function relationship of Yuehchukene II. The effect of C-6 indole rotation on anti-implantation activity
  作者：KF Cheng、TT Wong、KP Chan、YC Kong

  DOI：10.1016/0223-5234(92)90100-f

  日期：1992.3

  In a first attempts to define the structural requirements for the expression of anti-implantation activity in Yuehchukene (YCK), it was found that the relative position or planarity of the aromatic centres may be crucial. New synthetic routes leading to analogues with modification of C-7 substituents were established. Results indicated that a bulky group at C-7 that served to restrict the rotation of the C-6 indole was indispensable. Further steric hindrance by 2'-methyl would increase potency in all weak analogues. It was concluded that YCK required an optimal conformation that was defined by a narrowly-fixed angle between the, planes of the C-6 indole and the tetracyclic unit.