6-({(3R,6S)-6-[(1S)-1-amino-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl]tetrahydropyran-3-ylamino}methyl)-4H-pyrido[3,2-b][1,4]thiazin-3-one | 1198354-89-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-({(3R,6S)-6-[(1S)-1-amino-2-(7-methoxy-2-oxo-2H-quinolin-1-yl)ethyl]tetrahydropyran-3-ylamino}methyl)-4H-pyrido[3,2-b][1,4]thiazin-3-one
• 英文别名: 6-[[[(3R,6S)-6-[(1S)-1-amino-2-(7-methoxy-2-oxoquinolin-1-yl)ethyl]oxan-3-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]thiazin-3-one
• CAS: 1198354-89-0
• 化学式: C₂₅H₂₉N₅O₄S
• 分子量: 495.602
• InChiKey: VCAKNPMVTFGFKX-LMNJBCLMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  35
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  144
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• [4-(1-AMINO-ETHYL) -CYCLOHEXYL]-METHYL-AMINE AND [6-(1-AMINO-ETHYL) -TETRAHYDRO- PYRAN-3-YL]-METHYL-AMINE DERIVATIVES AS ANTIBACTERIALS
  申请人：Actelion Pharmaceuticals Ltd.

  公开号：EP2297107B1

  公开（公告）日：2013-11-13
• [4-(1-AMINO-EHTYL) - CYCLOHEXYL] -METHYL-AMINE AND [6-(1-AMINO-EHTYL) -TETRAHYDRO-PYRAN-3-YL] -METHYL-AMINE DERIVATIVES AS ANTIBACTERIALS
  申请人：Hubschwerlen Christian

  公开号：US20110082132A1

  公开（公告）日：2011-04-07

  The invention relates to antibacterial compounds of formula I wherein R 1 represents alkoxy or halogen; U, V and W each represent CH, or one of U, V and W represents N and the others each represent CH; A represents CH 2 or O; G is CH═CH—E wherein E represents a phenyl group mono- or di-substituted with halogen, or G is a group of one of the formulae hereafter wherein Z represent CH or N, Q represents O or S and K represents O or S; and salts of such compounds.
• US8349829B2
  申请人：——

  公开号：US8349829B2

  公开（公告）日：2013-01-08