dimethyl 1-benzyl-2-phenyl-1,2-dihydroquinoline-3,3(4H)-dicarboxylate | 1097259-53-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: dimethyl 1-benzyl-2-phenyl-1,2-dihydroquinoline-3,3(4H)-dicarboxylate
• 英文别名: Dimethyl 1-benzyl-2-phenyl-2,4-dihydroquinoline-3,3-dicarboxylate；dimethyl 1-benzyl-2-phenyl-2,4-dihydroquinoline-3,3-dicarboxylate
• CAS: 1097259-53-4
• 化学式: C₂₆H₂₅NO₄
• 分子量: 415.489
• InChiKey: ZIQFMWBACHVHGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  dimethyl 2-(2-(dibenzylamino)benzylidene)malonate 在 gadolinium(III) trifluoromethanesulfonate 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以70%的产率得到dimethyl 1-benzyl-2-phenyl-1,2-dihydroquinoline-3,3(4H)-dicarboxylate
  参考文献：
  名称：

  Lewis Acid Catalyzed Formation of Tetrahydroquinolines via an Intramolecular Redox Process

  摘要：

  Polycyclic tetrahydroquinolines were prepared by an efficient Lewis acid catalyzed 1,5-hydride shift, ring closure sequence. Gadolinium triflate was Identified as a catalyst that Is superior to scandium triflate as well as other Lewis acids. An approach toward a catalytic enantioselective variant Is also described.

  DOI：

  10.1021/ol802519r

文献信息

• Lewis Acid Catalyzed Formation of Tetrahydroquinolines via an Intramolecular Redox Process
  作者：Sandip Murarka、Chen Zhang、Marlena D. Konieczynska、Daniel Seidel

  DOI：10.1021/ol802519r

  日期：2009.1.1

  Polycyclic tetrahydroquinolines were prepared by an efficient Lewis acid catalyzed 1,5-hydride shift, ring closure sequence. Gadolinium triflate was Identified as a catalyst that Is superior to scandium triflate as well as other Lewis acids. An approach toward a catalytic enantioselective variant Is also described.