ethyl 1,3-bis(3-methoxybenzoyl)indolizine-2-carboxylate | 1352441-11-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl 1,3-bis(3-methoxybenzoyl)indolizine-2-carboxylate
• 英文别名: Ethyl 1,3-bis(3-methoxybenzoyl)indolizine-2-carboxylate
• CAS: 1352441-11-2
• 化学式: C₂₇H₂₃NO₆
• 分子量: 457.483
• InChiKey: MCORVMOSFXZACN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  83.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  吡啶 、 乙醛酸乙酯 、 2-溴-3‘-甲氧基苯乙酮 在 sodium carbonate 作用下， 以 乙腈 为溶剂， 反应 16.0h， 以58%的产率得到ethyl 1,3-bis(3-methoxybenzoyl)indolizine-2-carboxylate
  参考文献：
  名称：

  One-pot multicomponent synthesis of polysubstituted indolizines

  摘要：

  Concise and efficient four-component tandem approaches to polysubstituted indolizines have been developed under metal-free and mild aerobic conditions in refluxing acetonitrile. The mechanism of the novel reactions was proposed involving the formation of pyridinium ylides and alpha,beta-unsaturated ketones with subsequent 1,3-dipolar cycloaddition and aromatization reaction. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.10.083

文献信息

• One-pot multicomponent synthesis of polysubstituted indolizines
  作者：Zhenjun Mao、Xuejian Li、Xufeng Lin、Ping Lu、Yanguang Wang

  DOI：10.1016/j.tet.2011.10.083

  日期：2012.1

  Concise and efficient four-component tandem approaches to polysubstituted indolizines have been developed under metal-free and mild aerobic conditions in refluxing acetonitrile. The mechanism of the novel reactions was proposed involving the formation of pyridinium ylides and alpha,beta-unsaturated ketones with subsequent 1,3-dipolar cycloaddition and aromatization reaction. (C) 2011 Elsevier Ltd. All rights reserved.