(3Z)-3-[(E)-1,3-diphenylprop-2-enylidene]-4-ethenyl-1-(4-methylphenyl)sulfonylpyrrolidine | 1344999-88-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (3Z)-3-[(E)-1,3-diphenylprop-2-enylidene]-4-ethenyl-1-(4-methylphenyl)sulfonylpyrrolidine
• CAS: 1344999-88-7
• 化学式: C₂₈H₂₇NO₂S
• 分子量: 441.594
• InChiKey: MXQHPHMNSOELQB-RBSUEVEXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  45.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯乙烯 、 N-(4-bromobut-2-en-1-yl)-4-methyl-N-(3-phenylprop-2-yn-1-yl)benzenesulfonamide 在 palladium diacetate 、 potassium carbonate 、 三苯基膦 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 20.5h， 以50%的产率得到(3Z)-3-[(E)-1,3-diphenylprop-2-enylidene]-4-ethenyl-1-(4-methylphenyl)sulfonylpyrrolidine
  参考文献：
  名称：

  Construction of 3-allylidene-4-vinyltetrahydrofurans and 3-allylidene-4-vinylpyrrolidines via sequential domino allylation/olefination of C–C triple bonds

  摘要：

  An efficient method via sequential domino allylation/olefination of C-C triple bonds for the syntheses of five-membered heterocycles was developed by treatment 1,6-enynes with alkenes in the presence of a palladium catalyst. The configurations of the 1,3-dienes of the five-membered heterocycles are stereocontrolled. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.09.026

文献信息

• Construction of 3-allylidene-4-vinyltetrahydrofurans and 3-allylidene-4-vinylpyrrolidines via sequential domino allylation/olefination of C–C triple bonds
  作者：Tuan-jie Meng、Yimin Hu、Quansheng Zhao、Tao Yu、Shaowu Wang

  DOI：10.1016/j.tet.2011.09.026

  日期：2011.11

  An efficient method via sequential domino allylation/olefination of C-C triple bonds for the syntheses of five-membered heterocycles was developed by treatment 1,6-enynes with alkenes in the presence of a palladium catalyst. The configurations of the 1,3-dienes of the five-membered heterocycles are stereocontrolled. (C) 2011 Elsevier Ltd. All rights reserved.