| 225504-99-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 225504-99-4
• 化学式: C₄₀H₆₇NO₁₄
• 分子量: 785.97
• InChiKey: ZFJKEXVUBGWLFI-PDPYWIPOSA-N

反应信息

• 作为反应物：
  描述：

  在 sodium tetrahydroborate 作用下， 以 异丙醇 为溶剂， 以79%的产率得到[(2S,3R,4S,6R)-4-(dimethylamino)-2-[[(1R,2R,5R,6S,7S,8R,9R,11R,12S,13S,14R)-2-ethyl-9,12-dihydroxy-6-[(2S,4S,6S)-4-methoxy-4,6-dimethyloxan-2-yl]oxy-1,5,7,9,11,13-hexamethyl-4,16-dioxo-3,15,17-trioxabicyclo[12.3.0]heptadecan-8-yl]oxy]-6-methyloxan-3-yl] acetate
  参考文献：
  名称：

  Preparation of 9-deoxo-4″-deoxy-6,9-epoxyerythromycin lactams “motilactides”: Potent and orally active prokinetic agents

  摘要：

  A series of new, highly potent and orally active "motilactides", 9-deoxo-4 "-deoxy-6,9-epoxyerythromycin lactams was designed, synthesized, and evaluated for their gastrointestinal motor stimulating activity. These compounds were acid stable and showed good oral efficacy. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00111-5
• 作为产物：
  描述：

  乙酸酐 、 N,N'-羰基二咪唑 、 4''-deoxy-erythromycin A 在 4-二甲氨基吡啶 作用下， 生成
  参考文献：
  名称：

  Preparation of 9-deoxo-4″-deoxy-6,9-epoxyerythromycin lactams “motilactides”: Potent and orally active prokinetic agents

  摘要：

  A series of new, highly potent and orally active "motilactides", 9-deoxo-4 "-deoxy-6,9-epoxyerythromycin lactams was designed, synthesized, and evaluated for their gastrointestinal motor stimulating activity. These compounds were acid stable and showed good oral efficacy. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(98)00111-5