(1S)-N-diphenylphosphanyl-N-methyl-1-(2-phenylsulfanylphenyl)ethanamine | 1227795-25-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: (1S)-N-diphenylphosphanyl-N-methyl-1-(2-phenylsulfanylphenyl)ethanamine
• CAS: 1227795-25-6
• 化学式: C₂₇H₂₆NPS
• 分子量: 427.55
• InChiKey: ATHRIKPLBBFLPZ-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  28.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (1S)-N-methyl-1-(2-phenylsulfanylphenyl)ethanamine 、 二苯基氯化膦 在 三乙胺 作用下， 以 甲苯 为溶剂， 生成 (1S)-N-diphenylphosphanyl-N-methyl-1-(2-phenylsulfanylphenyl)ethanamine
  参考文献：
  名称：

  Preparation of S-Containing Aminophosphine and Phosphoramidite Ligands and Their Applications in Enantioselective C–C Bond Forming Reactions

  摘要：

  A series of phosphorus/sulfur ligands were readily prepared and successfully applied in the Pd-catalyzed enantioselective allylic substitution and Cu-catalyzed conjugated additions of cyclic enones, respectively. The Pd-catalyzed enantioselective allylic substitution showed the best yield of 98% with 74% ee. For the Cu-catalyzed conjugated additions of cyclic enones, the best yield of 100% with 76% ee at the temperature of -30 degrees C could be obtained.

  DOI：

  10.1007/s10562-010-0331-2
• 作为试剂：
  描述：

  (E)-1,3-diphenylprop-2-en-1-yl pivalate 、 丙二酸二甲酯 在 N,O-双三甲硅基乙酰胺 、 bis(η3-allyl-μ-chloropalladium(II)) 、 (1S)-N-diphenylphosphanyl-N-methyl-1-(2-phenylsulfanylphenyl)ethanamine 、 potassium acetate 作用下， 以 甲苯 为溶剂， 反应 12.0h， 生成 dimethyl 2-[(E)-(S)-1,3-diphenylallyl]-malonate 、 (R)-methyl 2-carbomethoxy-3,5-diphenylpent-4-enoate
  参考文献：
  名称：

  Preparation of S-Containing Aminophosphine and Phosphoramidite Ligands and Their Applications in Enantioselective C–C Bond Forming Reactions

  摘要：

  A series of phosphorus/sulfur ligands were readily prepared and successfully applied in the Pd-catalyzed enantioselective allylic substitution and Cu-catalyzed conjugated additions of cyclic enones, respectively. The Pd-catalyzed enantioselective allylic substitution showed the best yield of 98% with 74% ee. For the Cu-catalyzed conjugated additions of cyclic enones, the best yield of 100% with 76% ee at the temperature of -30 degrees C could be obtained.

  DOI：

  10.1007/s10562-010-0331-2

文献信息

• Preparation of S-Containing Aminophosphine and Phosphoramidite Ligands and Their Applications in Enantioselective C–C Bond Forming Reactions
  作者：Ju-Lan Zeng、Sai-Bo Yu、Zhong Cao、Dao-Wu Yang

  DOI：10.1007/s10562-010-0331-2

  日期：2010.6

  A series of phosphorus/sulfur ligands were readily prepared and successfully applied in the Pd-catalyzed enantioselective allylic substitution and Cu-catalyzed conjugated additions of cyclic enones, respectively. The Pd-catalyzed enantioselective allylic substitution showed the best yield of 98% with 74% ee. For the Cu-catalyzed conjugated additions of cyclic enones, the best yield of 100% with 76% ee at the temperature of -30 degrees C could be obtained.