(12E)-2,5,8-trioxabicyclo[12.4.0]octadeca-12,14-diene | 1236827-89-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (12E)-2,5,8-trioxabicyclo[12.4.0]octadeca-12,14-diene
• CAS: 1236827-89-6
• 化学式: C₁₅H₂₄O₃
• 分子量: 252.354
• InChiKey: FFUBKWWEXZDVEZ-QHHAFSJGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  6-(2-(2-(pent-4-en-1-yloxy)ethoxy)ethoxy)oct-1-en-7-yne 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 甲苯 为溶剂， 反应 24.0h， 以64%的产率得到(12E)-2,5,8-trioxabicyclo[12.4.0]octadeca-12,14-diene
  参考文献：
  名称：

  Synthesis of Small and Large Fused Bicyclic Compounds by Tandem Dienyne Ring-Closing Metathesis

  摘要：

  A tandem ring-closing metathesis reaction using ruthenium catalyst was carried out to synthesize various fused bicyclic compounds containing both small and large rings. Fast ring-closure of the small ring and slow ring-closure of the large ring resulted in the formation of only one Isomer. Further manipulation such as the Diels-Alder reaction was carried out to prepare a complex molecule containing multiple rings of different sizes.

  DOI：

  10.1021/ol101233k

文献信息

• Synthesis of Small and Large Fused Bicyclic Compounds by Tandem Dienyne Ring-Closing Metathesis
  作者：Hyeon Park、You-Lee Hong、Yongjoo B. Kim、Tae-Lim Choi

  DOI：10.1021/ol101233k

  日期：2010.8.6

  A tandem ring-closing metathesis reaction using ruthenium catalyst was carried out to synthesize various fused bicyclic compounds containing both small and large rings. Fast ring-closure of the small ring and slow ring-closure of the large ring resulted in the formation of only one Isomer. Further manipulation such as the Diels-Alder reaction was carried out to prepare a complex molecule containing multiple rings of different sizes.