2-bromo-5-chloro-3,6-dihydroxy-[1,4]benzoquinone | 26361-21-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-bromo-5-chloro-3,6-dihydroxy-[1,4]benzoquinone
• 英文别名: 2-Brom-5-chlor-3,6-dihydroxy-[1,4]benzochinon；2-Bromo-5-chloro-3,6-dihydroxycyclohexa-2,5-diene-1,4-dione
• CAS: 26361-21-7
• 化学式: C₆H₂BrClO₄
• 分子量: 253.436
• InChiKey: ISFFVAIWVFAFPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-溴-2-氯-6-硝基苯酚 在 氢氧化钾 、 水 、 溴 作用下， 生成 2-bromo-5-chloro-3,6-dihydroxy-[1,4]benzoquinone
  参考文献：
  名称：

  Ling, Journal of the Chemical Society, 1887, vol. 51, p. 786

  摘要：

  DOI：

文献信息

• Molecular Characterization in the VP7, VP4 and NSP4 Genes of Human Rotavirus Serotype 4 (G4) Isolated in Japan and Kenya
  作者：Satoshi Kudo、Yumei Zhou、Xin-Ru Cao、Shigeki Yamanishi、Shuji Nakata、Hiroshi Ushijima

  DOI：10.1111/j.1348-0421.2001.tb01286.x

  日期：2001.2

  AbstractThe VP7, VP4 and NSP4 genes of human rotavirus serotype 4 (G4) were analyzed to investigate intraserotypic variations. The techniques used included reverse transcription polymerase chain reaction with subtype specific primers, restriction fragment length polymorphism analysis and sequence analysis. Twelve isolates (nine from Japan and three from Kenya) and two standard strains (Hochi, Odelia) were G4A P[8] Wa group NSP4. A standard strain (ST3) was G4A P[6] Wa group NSP4 and a strain (VA70) was G4B P[8] Wa group NSP4. These results show G4 rotaviruses can be divided into three combinations at the moment.
• Ling; Baker, Journal of the Chemical Society, 1892, vol. 61, p. 592
  作者：Ling、Baker

  DOI：——

  日期：——
• Levy; Schultz, Justus Liebigs Annalen der Chemie, 1881, vol. 210, p. 163
  作者：Levy、Schultz

  DOI：——

  日期：——
• Cytokine Responses to Recombinant Cholera Toxin B Subunit Produced by<i>Bacillus brevis</i>as a Mucosal Adjuvant
  作者：Jun-ichi Maeyama、Masanori Isaka、Yoko Yasuda、Keiko Matano、Satoshi Kozuka、Tooru Taniguchi、Kunio Ohkuma、Kunio Tochikubo、Norihisa Goto

  DOI：10.1111/j.1348-0421.2001.tb01276.x

  日期：2001.2

  AbstractWe attempted to clarify the mechanism of the mucosal adjuvanticity of recombinant cholera toxin B subunit (rCTB), which is inherently uncontaminated with the holotoxin produced by Bacillus brevis and has a powerful mucosal adjuvant activity, on cytokine responses compared with that of cholera toxin (CT). rCTB had no ability to stimulate cyclic AMP formation in mouse peritoneal macrophages (Mφ). Cytokine production by non‐immunized Mφ cultured with rCTB or CT and by the spleen cells of mice co‐immunized intranasally with ovalbumin (OVA) and rCTB or CT was examined. rCTB alone did not induce interleukin (IL)‐1α/β or IL‐6 production by Mφ, but combination of rCTB with lipopolysaccharide (LPS) enhanced both IL‐1α/β production. Conversely, CT plus LPS suppressed IL‐1α/β production more than LPS alone. Both rCTB and CT suppressed IL‐12 secretion induced by interferon γ (IFN γ) plus LPS. IL‐2, IL‐4, IL‐5, and IL‐10 were secreted by mouse spleen cells restimulated with OVA after intranasal co‐administration of OVA together with rCTB, and in response to CT, the same cytokines were secreted. The different effect of rCTB on Mφ from that of CT may mean a difference between the mechanisms of rCTB and CT during the early stage of an immune response.
• Hantzsch, Chemische Berichte, 1889, vol. 22, p. 2829
  作者：Hantzsch

  DOI：——

  日期：——