3-(4,7-dihydro-1H-indol-2-yl)cyclopentan-1-one | 1227195-79-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(4,7-dihydro-1H-indol-2-yl)cyclopentan-1-one
• CAS: 1227195-79-0
• 化学式: C₁₃H₁₅NO
• 分子量: 201.268
• InChiKey: CLQNNSXLBPWZPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  32.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-(4,7-dihydro-1H-indol-2-yl)cyclopentan-1-one 在 对苯醌 作用下， 以 二氯甲烷 为溶剂， 反应 48.0h， 以590 mg的产率得到3-(1H-indol-2-yl)-cyclopentanone
  参考文献：
  名称：

  Synthesis of a new series of 2-vinylindoles and their cycloaddition reactivity

  摘要：

  The regioselective synthesis of 2-vinylindoles was achieved through the use of 4,7-dihydroindole 19. Reactions of these 2-vinylindoles as 4 pi-component gave 2,3-disubstitue indoles as well as the expected Diels-Alder products. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.02.080
• 作为产物：
  描述：

  2-环戊烯酮 、 4,7-dihydro-1H-indole 在 bismuth (III) nitrate pentahydrate 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 生成 3-(4,7-dihydro-1H-indol-2-yl)cyclopentan-1-one
  参考文献：
  名称：

  Synthesis of a new series of 2-vinylindoles and their cycloaddition reactivity

  摘要：

  The regioselective synthesis of 2-vinylindoles was achieved through the use of 4,7-dihydroindole 19. Reactions of these 2-vinylindoles as 4 pi-component gave 2,3-disubstitue indoles as well as the expected Diels-Alder products. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.02.080

文献信息

• Synthesis of a new series of 2-vinylindoles and their cycloaddition reactivity
  作者：Tayfun Arslan、Ali Enis Sadak、Nurullah Saracoglu

  DOI：10.1016/j.tet.2010.02.080

  日期：2010.4

  The regioselective synthesis of 2-vinylindoles was achieved through the use of 4,7-dihydroindole 19. Reactions of these 2-vinylindoles as 4 pi-component gave 2,3-disubstitue indoles as well as the expected Diels-Alder products. (C) 2010 Elsevier Ltd. All rights reserved.