2,4,6-Trichloro-N-(7,8-dimethoxy-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-yl)benzenesulfonamide | 376349-80-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,4,6-Trichloro-N-(7,8-dimethoxy-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-yl)benzenesulfonamide
• 英文别名: 2,4,6-trichloro-N-(7,8-dimethoxy-4,5-dihydrobenzo[e][1,3]benzothiazol-2-yl)benzenesulfonamide
• CAS: 376349-80-3
• 化学式: C₁₉H₁₅Cl₃N₂O₄S₂
• 分子量: 505.83
• InChiKey: DYXBPGZNZNQXCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  7,8-dimethoxy-4,5-dihydro-naphtho[1,2-d]thiazol-2-ylamine 、 2,4,6-三氯苯磺酰氯 以to give a yellow powder (6.5 mg) with a purity of 86%的产率得到
  参考文献：
  名称：

  Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1

  摘要：

  本发明涉及具有式（I）的化合物，以及包含这些化合物的药物组合物，它们的制备过程，以及这些化合物在医学上的使用以及用于制备对人类11-β-羟基类固醇脱氢酶1型酶起作用的药物。

  公开号：

  US07132436B2

文献信息

• Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
  申请人：——

  公开号：US20030166689A1

  公开（公告）日：2003-09-04

  The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-&bgr;-hydroxysteroid dehydrogenase type 1 enzyme.

  本发明涉及具有式(I)的化合物，以及包含这些化合物的药物组合物，用于它们的制备过程，以及这些化合物在医学中的使用，以及用于制备作用于人类11-β-羟基甾酮脱氢酶类型1酶的药物的制剂。
• INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1
  申请人：BIOVITRUM AB

  公开号：EP1283832A1

  公开（公告）日：2003-02-19
• US7132436B2
  申请人：——

  公开号：US7132436B2

  公开（公告）日：2006-11-07
• [EN] INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1<br/>[FR] INHIBITEURS DE 11-BETA-HYDROXY-STEROIDE-DESHYDROGENASE DE TYPE 1
  申请人：BIOVITRUM AB

  公开号：WO2001090092A1

  公开（公告）日：2001-11-29

  The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, to processes for their preparation, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
• [EN] NEW USE IV<br/>[FR] UTILISATION IV
  申请人：BIOVITRUM AB

  公开号：WO2004112783A1

  公开（公告）日：2004-12-29

  The invention relates to a method for promoting wound healing, said method comprising administering to a mammal, including man, in need of such promotion an effective amount of an inhibitor of 11-ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1), said 11ß-HSD1 inhibitor having the formula (I) wherein T, A, and B are as defined in the specification. These compounds may also be used in the manufacture of a medicament for promoting wound healing.