1L-N,N'-bis-phenoxycarbonyl-O⁴-(3-phenoxycarbonylamino-α-D-3-deoxy-glucopyranosyl)-O⁶-(6-phenoxycarbonylamino-α-D-6-deoxy-glucopyranosyl)-2-deoxy-streptamine | 69783-70-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1L-N,N'-bis-phenoxycarbonyl-O⁴-(3-phenoxycarbonylamino-α-D-3-deoxy-glucopyranosyl)-O⁶-(6-phenoxycarbonylamino-α-D-6-deoxy-glucopyranosyl)-2-deoxy-streptamine
• CAS: 69783-70-6
• 化学式: C₄₆H₅₂N₄O₁₉
• 分子量: 964.934
• InChiKey: MUJIYFACCILCPP-ZHWGFVKASA-N

反应信息

• 作为反应物：
  描述：

  1L-N,N'-bis-phenoxycarbonyl-O⁴-(3-phenoxycarbonylamino-α-D-3-deoxy-glucopyranosyl)-O⁶-(6-phenoxycarbonylamino-α-D-6-deoxy-glucopyranosyl)-2-deoxy-streptamine 在 ion-exchange resin - form> 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 1L-O⁴-(3-amino-N,O²-carbonyl-α-D-3-deoxy-glucopyranosyl)-O⁶-(6-amino-N,O⁴-carbonyl-α-D-6-deoxy-glucopyranosyl)-N,N'-carbonyl-2-deoxy-streptamine
  参考文献：
  名称：

  Aminoglycoside antibiotics. 2. N, N-Dialkylkanamycins

  摘要：

  N6',N3''-Dialkyl derivatives of kanamycins A and B were prepared regiospecifically from the parent antibiotics. Although the dimethyl and diethyl derivatives of kanamycin A were inactive in standard antibacterial assays, the dimethyl derivative of kanamycin B showed moderate activity, especially against various strains of Pseudomonas aeruginosa. A method for the selective dimethylation of the 3''-amino group of kanamycin A also was developed.

  DOI：

  10.1021/jm00190a015