scyllo-inositol monophosphate | 155154-51-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: scyllo-inositol monophosphate
• 英文别名: O-phosphono-scyllo-inositol；1r-Phosphonooxy-cyclohexanpentol-(2t,3c,4t,5c,6t)；O-Phosphono-scyllo-inosit
• CAS: 155154-51-1
• 化学式: C₆H₁₃O₉P
• 分子量: 260.138
• InChiKey: INAPMGSXUVUWAF-CDRYSYESSA-N

反应信息

• 作为产物：
  描述：

  O-phosphono-penta-O-acetyl-scyllo-inositol 在 sodium methylate 作用下， 生成 scyllo-inositol monophosphate
  参考文献：
  名称：

  Synthesis of Inositol-5-monophosphoric Acid and Scyllitol Monophosphoric Acid

  摘要：

  DOI：

  10.1021/ja01179a069

文献信息

• Insulin activity messengers, their precursors and uses thereof
  申请人：ROCKEFELLER UNIVERSITY

  公开号：EP0245956A2

  公开（公告）日：1987-11-19

  An insulin activity messenger material and its precursor material are disclosed which have been isolated from hapatic plasma membrane cells that have been incubated with an enzyme known as a phosphatidylinositol-specific phospholipase C. The messenger material comprises a carbohydrate-based compound that exhibits the ability to modulate the activity of the insulin-sensitive enzymes pyruvate dehydrogenase, adenylate cyclase, acetyl CoA carboxylase, and low Km CAMP phosphodiesterase, and thereby effectuate the activity of insulin on the cellular level. The precursor material comprises an inositol containing glycolipid capable of phosphodiesteratic cleavage by a phosphatidylinositol-specific phospholipase C. The enzyme phosphatidylinositol-glycan specific phospholipase C has also been purified and found to participate in many of the activities identified with respect to the messenger and its precursor. Numerous diagnostic and therapeutic utilities are proposed, and testing procedures, materials in kit form and pharmaceutical compositions are likewise set forth.

  本发明公开了一种胰岛素活性信使物质及其前体物质，它们是从与一种称为磷脂酰肌醇特异性磷脂酶 C 的酶培养过的单肝浆膜细胞中分离出来的。这种信使材料包括一种基于碳水化合物的化合物，它能够调节对胰岛素敏感的丙酮酸脱氢酶、腺苷酸环化酶、乙酰 CoA 羧化酶和低 Km CAMP 磷酸二酯酶的活性，从而在细胞水平上影响胰岛素的活性。前体物质包括一种含肌醇的糖脂，能够被磷脂酰肌醇特异性磷脂酶 C 磷酸二酯化裂解。磷脂酰肌醇-糖特异性磷脂酶 C 也已被纯化，并发现它参与了许多与信使及其前体有关的活动。此外，还提出了许多诊断和治疗方法，以及测试程序、试剂盒形式的材料和药物组合物。
• USE OF INOSITOLPHOSPHATES FOR PREPARING MEDICAMENT
  申请人：PERSTORP AB

  公开号：EP0505452B1

  公开（公告）日：1996-06-19
• US4341558A
  申请人：——

  公开号：US4341558A

  公开（公告）日：1982-07-27
• US4839466A
  申请人：——

  公开号：US4839466A

  公开（公告）日：1989-06-13
• US4906468A
  申请人：——

  公开号：US4906468A

  公开（公告）日：1990-03-06