| 657405-07-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 657405-07-7
• 化学式: C₂₈H₅₄O₄SiSn
• 分子量: 601.53
• InChiKey: KVJKOYNQHKNBOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.78
• 重原子数：
  34
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-烯丙基-2-(2-丙炔基)丙二酸二乙酯 、 叔丁基锡烷 在 tris(dibenzylideneacetone)dipalladium (0) 、 二甲基苯基磷 作用下， 以 四氢呋喃 为溶剂， 以6%的产率得到
  参考文献：
  名称：

  Further studies on palladium-catalyzed bismetallative cyclization of enynes in the presence of Bu3SnSiMe3

  摘要：

  Bismetallative cyclization of enynes with Bu3SnSiMe3 catalyzed by Pd(0) complex was realized for the first time, which gives cyclized products containing a vinylsilane moiety and a homoallyltin moiety in good yield. In this cyclization, Pd-2(dba)(3)(CHCl3)-C-. or Pd(OH)2 on charcoal is effective as a Pd(0) catalyst and the addition of a phosphine ligand increased the formation of alkyne bismetallation by-product. On the other hand, it was found that a nucleophilic N-heterocyclic carbene could be utilized as a ligand for this cyclization. The utility of the cyclized products obtained from this cyclization in synthetic organic chemistry have been proven by transformation into cyclopropanol derivatives. (C) 2003 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/s0022-328x(03)00601-6

文献信息

• Palladium-Catalyzed Bismetallative Cyclization of Enynes
  作者：Miwako Mori、Tomohiro Hirose、Hideaki Wakamatsu、Noriko Imakuni、Yoshihiro Sato

  DOI：10.1021/om000979x

  日期：2001.5.1

  Enynes were reacted with Me3SiSnBu3 in the presence of Pd(2)dba(3). CHCl3 or Pd(OH)(2) on charcoal to give cyclized products containing a vinylsilane moiety and a homoallyltin moiety in good yield.
• Further studies on palladium-catalyzed bismetallative cyclization of enynes in the presence of Bu3SnSiMe3
  作者：Yoshihiro Sato、Noriko Imakuni、Tomohiro Hirose、Hideaki Wakamatsu、Miwako Mori

  DOI：10.1016/s0022-328x(03)00601-6

  日期：2003.12

  Bismetallative cyclization of enynes with Bu3SnSiMe3 catalyzed by Pd(0) complex was realized for the first time, which gives cyclized products containing a vinylsilane moiety and a homoallyltin moiety in good yield. In this cyclization, Pd-2(dba)(3)(CHCl3)-C-. or Pd(OH)2 on charcoal is effective as a Pd(0) catalyst and the addition of a phosphine ligand increased the formation of alkyne bismetallation by-product. On the other hand, it was found that a nucleophilic N-heterocyclic carbene could be utilized as a ligand for this cyclization. The utility of the cyclized products obtained from this cyclization in synthetic organic chemistry have been proven by transformation into cyclopropanol derivatives. (C) 2003 Elsevier B.V. All rights reserved.