2,2-Dimethyl-propionic acid 3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester | 370579-50-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2,2-Dimethyl-propionic acid 3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester
• 英文别名: [3-[(3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-2,6-dioxopyrimidin-1-yl]methyl 2,2-dimethylpropanoate
• CAS: 370579-50-3
• 化学式: C₁₈H₂₆N₂O₈
• 分子量: 398.413
• InChiKey: JAUZHZVFSGTVTM-FMKGYKFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  115
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  N-(o-nitrobenzenesulfonyl)-L-phenylalanine tert-butyl ester 、 2,2-Dimethyl-propionic acid 3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 以93%的产率得到(S)-2-[{(3aR,4R,6R,6aR)-6-[3-(2,2-Dimethyl-propionyloxymethyl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl}-(2-nitro-benzenesulfonyl)-amino]-3-phenyl-propionic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis of novel amino acid carbohydrate hybrids via Mitsunobu glycosylation of nitrobenzenesulfonamides

  摘要：

  Amino acid derived 2-nitrobenzenesulfonamides were successfully condensed under Mitsunobu conditions with the primary alcohol of various saccharide and nucleoside derivatives to furnish the fully protected hybrids in excellent yield. One such hybrid was incorporated into a short peptide sequence in good overall yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01062-0
• 作为产物：
  描述：

  2’,3’邻异亚丙基尿苷 、 alkaline earth salt of/the/ methylsulfuric acid 生成 2,2-Dimethyl-propionic acid 3-((3aR,4R,6R,6aR)-6-hydroxymethyl-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-ylmethyl ester
  参考文献：
  名称：

  Synthesis of novel amino acid carbohydrate hybrids via Mitsunobu glycosylation of nitrobenzenesulfonamides

  摘要：

  Amino acid derived 2-nitrobenzenesulfonamides were successfully condensed under Mitsunobu conditions with the primary alcohol of various saccharide and nucleoside derivatives to furnish the fully protected hybrids in excellent yield. One such hybrid was incorporated into a short peptide sequence in good overall yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)01062-0

文献信息

• Synthesis of novel amino acid carbohydrate hybrids via Mitsunobu glycosylation of nitrobenzenesulfonamides
  作者：John J. Turner、Dmitri V. Filippov、Mark Overhand、Gijs A. van der Marel、Jacques H. van Boom

  DOI：10.1016/s0040-4039(01)01062-0

  日期：2001.8

  Amino acid derived 2-nitrobenzenesulfonamides were successfully condensed under Mitsunobu conditions with the primary alcohol of various saccharide and nucleoside derivatives to furnish the fully protected hybrids in excellent yield. One such hybrid was incorporated into a short peptide sequence in good overall yield. (C) 2001 Elsevier Science Ltd. All rights reserved.