8-hydroxy-2-[2(E)-(3,4-dihydroxy-5-nitrophenyl)ethenyl]-7-quinoline carboxylic acid | 1204762-73-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-hydroxy-2-[2(E)-(3,4-dihydroxy-5-nitrophenyl)ethenyl]-7-quinoline carboxylic acid
• 英文别名: 2-[(E)-2-(3,4-dihydroxy-5-nitro-phenyl)vinyl]-8-hydroxy-quinoline-7-carboxylic acid；2-[(E)-2-(3,4-dihydroxy-5-nitrophenyl)ethenyl]-8-hydroxyquinoline-7-carboxylic acid
• CAS: 1204762-73-1
• 化学式: C₁₈H₁₂N₂O₇
• 分子量: 368.302
• InChiKey: OZDWQXZPTXGCKJ-DAFODLJHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  157
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• Styrylquinolines, their process of preparation and their therapeutic uses
  申请人：BioAlliance Pharma

  公开号：EP2147913A1

  公开（公告）日：2010-01-27

  The present invention concerns new substituted styrylquinolines, their process of preparation and their therapeutic uses as integrase inhibitors and/or for the treatment and/or prevention of HIV.

  本发明涉及新的取代苯乙烯基喹啉化合物，其制备方法以及它们作为整合酶抑制剂和/或用于治疗和/或预防HIV的治疗用途。
• [EN] STYRYLQUINOLINES, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTIC USES<br/>[FR] STYRYLQUINOLINES, LEUR PROCÉDÉ DE PRÉPARATION ET LEURS UTILISATIONS THÉRAPEUTIQUES
  申请人：BIOALLIANCE PHARMA

  公开号：WO2010010147A1

  公开（公告）日：2010-01-28

  The present invention concerns new substituted styrylquinolines, their process of preparation and their therapeutic uses as integrase inhibitors and/or for the treatment and/or prevention of HIV.