Methylsilicon | 992-94-9

• 分子结构分类: 有机化合物 - 碳氢化合物衍生物
• 英文名称: Methylsilicon
• CAS: 992-94-9
• 化学式: CH3Si
• 分子量: 43.12
• InChiKey: NCWQJOGVLLNWEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  2
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  正戊醛 、 氢氧化钾 、 环戊酮 、 硫酸 、 Methylsilicon 、 二乙二醇乙醚 在 sodium hydroxide 、 2-亚戊基环戊酮 作用下， 以 水 为溶剂， 反应 8.0h， 生成 2-(1-羟基戊基)-1-环戊酮
  参考文献：
  名称：

  Process for producing cycloakanone derivatives

  摘要：

  本发明提供了一种高产率和选择性制备2-(1-羟基烷基)环烷酮和/或2-(1-羟基芳基)环烷酮的方法，以及使用该方法制备环烷酮衍生物作为香料材料和生理活性物质的方法。公开了制备化合物(3)的方法，该方法包括将环烷酮和含有羧酸(1)的醛(2)在水和碱性催化剂存在下进行醛缩反应，其中所添加的碱性催化剂的摩尔量（以下简称A）不少于醛(2)中所含的羧酸(1)的摩尔量（以下简称B），且A与B之间的差值，即(A-B)每摩尔醛(2)不超过0.06摩尔。同时，本发明还提供了使用上述方法获得的化合物(3)制备化合物(7)和(8)的方法。其中n为1或2的整数，R1代表H或C1至C8烷基等，R2代表C1至C3烷基。

  公开号：

  US20040171850A1

文献信息

• Process for producing cycloakanone derivatives
  申请人：KAO CORPORATION

  公开号：US20040171850A1

  公开（公告）日：2004-09-02

  The present invention provides a process for producing 2-(1-hydroxyalkyl)cycloalkanone and/or 2-(1-hydroxyaryl)cycloalkanone in high yield and selectivity, as well as a process using the same to produce a cycloalkanone derivative useful as a perfume material and a physiologically active substance. Disclosed is a process for producing compound (3), which includes subjecting a cycloalkanone, and aldehyde (2) containing carboxylic acid (1), to aldol condensation in the presence of water and a basic catalyst, wherein the molar amount (referred to hereinafter as A) of the basic catalyst added is not less than the molar amount (referred to hereinafter as B) of the carboxylic acid (1) contained in the aldehyde (2) and the difference between A and B, that is, (A-B) is 0.06 mol or less per mol of the aldehyde (2), as well as a process for producing compounds (7) and (8) by using the compound (3) obtained by the above process. 1 wherein n is an integer of 1 or 2, R 1 represents H or a C1 to C8 alkyl group or the like, and R 2 represents a C1 to C3 alkyl group.

  本发明提供了一种高产率和选择性制备2-(1-羟基烷基)环烷酮和/或2-(1-羟基芳基)环烷酮的方法，以及使用该方法制备环烷酮衍生物作为香料材料和生理活性物质的方法。公开了制备化合物(3)的方法，该方法包括将环烷酮和含有羧酸(1)的醛(2)在水和碱性催化剂存在下进行醛缩反应，其中所添加的碱性催化剂的摩尔量（以下简称A）不少于醛(2)中所含的羧酸(1)的摩尔量（以下简称B），且A与B之间的差值，即(A-B)每摩尔醛(2)不超过0.06摩尔。同时，本发明还提供了使用上述方法获得的化合物(3)制备化合物(7)和(8)的方法。其中n为1或2的整数，R1代表H或C1至C8烷基等，R2代表C1至C3烷基。
• Process for producing cycloalkanone derivatives
  申请人：Kao Corporation

  公开号：US07161041B2

  公开（公告）日：2007-01-09

  The present invention provides a process for producing 2-(1-hydroxyalkyl)cycloalkanone and/or 2-(1-hydroxyaryl)cycloalkanone in high yield and selectivity, as well as a process using the same to produce a cycloalkanone derivative useful as a perfume material and a physiologically active substance. Disclosed is a process for producing compound (3), which includes subjecting a cycloalkanone, and aldehyde (2) containing carboxylic acid (1), to aldol condensation in the presence of water and a basic catalyst, wherein the molar amount (referred to hereinafter as A) of the basic catalyst added is not less than the molar amount (referred to hereinafter as B) of the carboxylic acid (1) contained in the aldehyde (2) and the difference between A and B, that is, (A−B) is 0.06 mol or less per mol of the aldehyde (2), as well as a process for producing compounds (7) and (8) by using the compound (3) obtained by the above process. wherein n is an integer of 1 or 2, R1 represents H or a C1 to C8 alkyl group or the like, and R2 represents a C1 to C3 alkyl group.

  本发明提供了一种高产率和选择性制备2-(1-羟基烷基)环烷酮和/或2-(1-羟基芳基)环烷酮的方法，以及使用该方法制备用作香料材料和生理活性物质的环烷酮衍生物的方法。公开了制备化合物(3)的方法，包括将环烷酮和含有羧酸(1)的醛(2)在水和碱性催化剂的存在下进行醛缩反应，其中添加的碱性催化剂的摩尔量（以下简称A）不少于醛(2)中所含羧酸(1)的摩尔量（以下简称B），且A和B之间的差值即(A-B)每摩尔醛(2)不超过0.06摩尔。同时，本发明还提供了使用上述方法获得的化合物(3)制备化合物(7)和(8)的方法。其中n为1或2的整数，R1代表氢或C1到C8烷基等，R2代表C1到C3烷基。