2-(1,3-Diphenylprop-2-ynyl)phenol | 133503-44-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2-(1,3-Diphenylprop-2-ynyl)phenol
• CAS: 133503-44-3
• 化学式: C₂₁H₁₆O
• 分子量: 284.357
• InChiKey: MJIHAXZCQWOSST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1,3-二苯基-2-丙炔-1-醇 、 苯酚 在 cerium triflate 作用下， 以 硝基甲烷 为溶剂， 反应 0.5h， 以92%的产率得到4-hydroxy-1-(1,3-diphenylprop-2-ynyl)benzene
  参考文献：
  名称：

  Propargylation of aromatic compounds using Ce(OTf)3 as catalyst

  摘要：

  Ce(OTf)(3) was successfully employed as catalyst for the activation of the hydroxyl group in the Friedel-Crafts reaction of aromatic compounds with propargylic alcohols in nitromethane. The products were obtained in good to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.01.046

文献信息

• Substituted 2-alkynylphenols with anti-inflammatory action, a process for their preparation and pharmaceutical compositions thereof
  申请人：CAMILLO CORVI S.p.A.

  公开号：EP0401517B1

  公开（公告）日：1993-11-03
• Propargylation of aromatic compounds using Ce(OTf)3 as catalyst
  作者：Claudio C. Silveira、Samuel R. Mendes、Guilherme M. Martins

  DOI：10.1016/j.tetlet.2012.01.046

  日期：2012.3

  Ce(OTf)(3) was successfully employed as catalyst for the activation of the hydroxyl group in the Friedel-Crafts reaction of aromatic compounds with propargylic alcohols in nitromethane. The products were obtained in good to excellent yields. (C) 2012 Elsevier Ltd. All rights reserved.