Sorbose-6-phosphate | 136598-65-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Sorbose-6-phosphate
• 英文别名: [(2R,3S,4R)-2,3,4,6-tetrahydroxy-5-oxohexyl] dihydrogen phosphate
• CAS: 136598-65-7
• 化学式: C₆H₁₃O₉P
• 分子量: 260.138
• InChiKey: GSXOAOHZAIYLCY-SRQIZXRXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.3
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  165
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• NOVEL COCRYSTALLIZATION
  申请人：CHILDS Scott L.

  公开号：US20090281195A1

  公开（公告）日：2009-11-12

  The present disclosure relates to novel cocrystals and novel methods for cocrystallization. In particular, the disclosure includes cocrystals comprising a salt of an active agent, such as a chloride salt of an active pharmaceutical ingredient. The present disclosure also relates to methods of preparing cocrystals and methods for screening for solid state phases.

  本公开涉及新型共晶体和新型共晶化方法。具体而言，公开包括由活性剂的盐组成的共晶体，例如活性药物成分的氯化物盐。本公开还涉及制备共晶体的方法和筛选固态相的方法。
• ENERGETIC COCRYSTALS FOR TREATMENT OF A SUBTERRANEAN FORMATION
  申请人：HALLIBURTON ENERGY SERVICES, INC.

  公开号：US20160177698A1

  公开（公告）日：2016-06-23

  The present invention relates to energetic cocrystals, and to methods for using the same for treatment of a subterranean formation. In various embodiments, the present invention provides a method of treating a subterranean formation, the method including obtaining or providing a composition including energetic cocrystals. Each energetic cocrystal independently includes an energetic compound and a secondary material. The method also includes placing the composition in a subterranean formation.

  本发明涉及具有能量共晶体的相关技术，以及使用这些技术治疗地下地层的方法。在各种实施例中，本发明提供了一种治疗地下地层的方法，该方法包括获得或提供包括能量共晶体的组合物。每个能量共晶体独立地包括一个能量化合物和一个辅助材料。该方法还包括将该组合物放置在地下地层中。
• Präparat zur Wirkstoffapplikation in Kleinsttröpfchenform
  申请人：Cevc, Gregor, Prof. Dr.

  公开号：EP0475160A1

  公开（公告）日：1992-03-18

  Die Erfindung betrifft ein Präparat zur Applikation von Wirkstoffen in Form kleinster, insbesondere mit einer membranartigen Hülle aus einer oder wenigen Lagen amphiphiler Moleküle bzw. mit einer amphiphilen Trägersubstanz versehenen Flüssigkeitströpfchen, insbesondere zum Transport des Wirkstoffes in und durch natürliche Barrieren und Konstriktionen wie Häute und dergleichen. Das Präparat weist einen Gehalt einer randaktiven Substanz auf, der bis zu 99 Mol.-% des Gehaltes dieser Substanz entspricht, durch den der Solubilisierungspunkt der Tröpfchen erreicht wird. Das Präparat eignet sich zur nichtinvasiven Verabreichung von Antidiabetica, insbesondere von Insulin. Die Erfindung betrifft außerdem ein Verfahren zur Herstellung solcher Präparate.

  本发明涉及一种以微小液滴形式施用活性物质的制剂，特别是具有一层或几层两亲性分子或两亲性载体物质的膜状包膜，尤其是用于将活性物质输送到或通过皮肤等天然屏障和收缩物。制剂中边缘活性物质的含量最高可达 99 摩尔%，从而达到液滴的溶解点。该制剂适用于非侵入性给药抗糖尿病药物，特别是胰岛素。本发明还涉及生产这种制剂的工艺。
• SORBITOL KINASE, PROCESS FOR PRODUCING THE SAME, AND SUBSTANTIALLY PURE MICROORGANISM
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：EP0784092A1

  公开（公告）日：1997-07-16

  A sorbitol kinase having at least the following physicochemical properties: 1) enzymatic action: utilizing mainly ATP, but not substantially phosphoenolpyruvate, as the phosphate donor catalyzing the following reaction: sorbitol + ATP → sorbitol 6-phosphate + ADP;(2) substrate specificity: having the substrate specificity for sorbitol; (3) N-terminal amino acid sequence: containing the following sequence: Met-Arg-Ile-Gly-Ile-Asp-Leu-Gly-Gly-Thr-Lys-Thr-Glu-Val-Ile-Ala-Leu-Ser-Glu-Gln; (4) thermostability: stable at least up to 60 °C when a 100 mM tris-HCl buffer (pH: 8.5, containing 0.5 U/ml of sorbitol kinase) is heated for 15 minutes at various temperatures and the residual activity is measured.

  至少具有以下理化性质的山梨醇激酶：1）酶促作用：主要利用 ATP，但基本上不利用磷酸烯醇丙酮酸作为磷酸供体，催化以下反应：山梨醇 + ATP → 6-磷酸山梨醇 + ADP；（2）底物特异性：对山梨醇具有底物特异性；（3）N-端氨基酸序列：包含以下序列：Met-Arg-Ile-Gly-Ile-Asp-Leu-Gly-Gly-Thr-Lys-Thr-Glu-Val-Ile-Ala-Leu-Ser-Glu-Gln；(4) 热稳定性：在不同温度下，将 100 mM tris-HCl 缓冲液（pH：8.5，含 0.5 U/ml 山梨醇激酶）加热 15 分钟并测量残余活性，其稳定性至少可达 60 ℃。
• Probe compound for detecting and isolating enzymes and means and methods using the same
  申请人：Helmholtz-Zentrum für Infektionsforschung GmbH

  公开号：EP2230312A1

  公开（公告）日：2010-09-22

  The present invention relates to a probe compound that can comprise any substrate or metabolite of an enzymatic reaction in addition to an indicator component, such as, for example, a fluorescence dye, or the like. Moreover, the present invention relates to means for detecting enzymes in form of an array, which comprises any number of probe compounds of the invention which each comprise a different metabolite of interconnected metabolites representing the central pathways in all forms of life. Moreover, the present invention relates to a method for detecting enzymes involving the application of cell extracts or the like to the array of the invention which leads to reproducible enzymatic reactions with the substrates. These specific enzymatic reactions trigger the indicator (e.g. a fluorescence signal) and bind the enzymes to the respective cognate substrates. Moreover, the invention relates to means for isolating enzymes in form of nanoparticles coated with the probe compound of the invention. The immobilisation of the cognate substrates or metabolites on the surface of nanoparticles by means of the probe compounds allows capturing and isolating the respective enzyme, e.g. for subsequent sequencing.

  本发明涉及一种探针化合物，它可以包括酶反应的任何底物或代谢物，此外还包括指示成分，例如荧光染料或类似物。此外，本发明还涉及以阵列形式检测酶的方法，该阵列由任意数量的本发明探针化合物组成，每种探针化合物由代表所有生命形式中中心途径的相互关联的代谢物中的不同代谢物组成。此外，本发明还涉及一种检测酶的方法，该方法涉及将细胞提取物或类似物应用于本发明的阵列，从而导致与底物发生可重复的酶反应。这些特定的酶反应会触发指示剂（如荧光信号），并将酶与各自的同源底物结合。此外，本发明还涉及以涂覆有本发明探针化合物的纳米颗粒形式分离酶的方法。通过探针化合物将同源底物或代谢物固定在纳米颗粒表面，可以捕获和分离相应的酶，例如用于后续测序。