(R,E)-1-(3-bromophenyl)-6,6,6-trifluoro-5-hydroxy-5-phenylhex-1-en-3-one | 1620209-03-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: (R,E)-1-(3-bromophenyl)-6,6,6-trifluoro-5-hydroxy-5-phenylhex-1-en-3-one
• 英文别名: (E,5R)-1-(3-bromophenyl)-6,6,6-trifluoro-5-hydroxy-5-phenylhex-1-en-3-one
• CAS: 1620209-03-1
• 化学式: C₁₈H₁₄BrF₃O₂
• 分子量: 399.207
• InChiKey: FYFIHQUBCPTURM-OAGJVSPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,2,2-三氟苯乙酮 、 (E)-4-(3-溴苯基)-丁-3-烯-2-酮 在 (1S)-2-(3H-dinaphtho[2,1-c:1',2'-e]azepin-4(5H)-yl)-1-phenylethanamine 、 苯甲酸 作用下， 以 甲苯 为溶剂， 反应 36.0h， 以83%的产率得到
  参考文献：
  名称：

  Enantioselective aldol reactions of α,β-unsaturated ketones with trifluoroacetophenone catalyzed by a chiral primary amine

  摘要：

  Chiral primary amine catalyzed direct asymmetric aldol reactions of ketones with trifluoroacetophenone, afforded trifluoromethylated beta-hydroxycarbonyl aldol products bearing a quaternary carbon stereogenic center in high yields (up to 93% yield) and with high to excellent enantioselectivities of up to 99% ee. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2014.05.005

文献信息

• Enantioselective aldol reactions of α,β-unsaturated ketones with trifluoroacetophenone catalyzed by a chiral primary amine
  作者：Jing Lin、Tairan Kang、Quanzhong Liu、Long He

  DOI：10.1016/j.tetasy.2014.05.005

  日期：2014.6

  Chiral primary amine catalyzed direct asymmetric aldol reactions of ketones with trifluoroacetophenone, afforded trifluoromethylated beta-hydroxycarbonyl aldol products bearing a quaternary carbon stereogenic center in high yields (up to 93% yield) and with high to excellent enantioselectivities of up to 99% ee. (C) 2014 Elsevier Ltd. All rights reserved.