dichloro-dihydroxo-(N-decyl)-ethylenediamine-platinum(IV) | 238735-42-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: dichloro-dihydroxo-(N-decyl)-ethylenediamine-platinum(IV)
• 英文别名: N'-decylethane-1,2-diamine;dichloroplatinum(2+);dihydroxide
• CAS: 238735-42-7
• 化学式: C₁₂H₃₀Cl₂N₂O₂Pt
• 分子量: 500.368
• InChiKey: PMUUHYXLCXHTQV-UHFFFAOYSA-J

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  dichloro-(N-decyl)-ethylenediamine-platinum(II) 、 双氧水 以 水 为溶剂， 以73%的产率得到dichloro-dihydroxo-(N-decyl)-ethylenediamine-platinum(IV)
  参考文献：
  名称：

  Synthesis and biological activity of cis-dichloro mono- and bis(platinum) complexes with N-alkyl-ethylenediamine ligands

  摘要：

  Mono- and bis(platinum) complexes containing N-alkyl-ethylenediamine units of the type {cis-PtCl2[H2NCH2CH2NH(CH2)nCH(3)]} (n = 8, 9, 11, 15) and [{cis-PtCl2(H2NCH2CH2NH)}(2)(CH2)(n)] (n = 6, 8, 10, 12) and their corresponding dihydroxo-platinum(IV) complexes were synthesized. The structures of the metal chelates were derived from elemental analyses and their H-1, C-13, IR spectra. The length of the aliphatic chains has been varied systematically, in order to increase the lipophilicity. Enlargement of the linker could also lead to more flexibility of one platinum sphere in reference to the attached DNA species. Using in vitro cytotoxicity tests it is shown that the biological activity of the bis(platinum) complexes increased, up to n = 12, with the length of the linker. The longest linker in the ligands resulted in the most effective bis(platinum) complexes against L1210 murine leukemia cells. (C) 1999 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0020-1693(99)00156-5