N-(2,6-dichloropyridin-4-yl)-1-[3-(pyridin-3-yl)phenyl]-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide | 694489-52-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-(2,6-dichloropyridin-4-yl)-1-[3-(pyridin-3-yl)phenyl]-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide
• 英文别名: N-(3,5-dichloropyridin-4-yl)-4-oxo-1-(3-pyridin-3-ylphenyl)-1,8-naphthyridine-3-carboxamide
• CAS: 694489-52-6
• 化学式: C₂₅H₁₅Cl₂N₅O₂
• 分子量: 488.332
• InChiKey: STEDRGGTWQAHOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88.1
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Method of preparing inhibitors of phosphodiesterase-4
  申请人：——

  公开号：US20040102472A1

  公开（公告）日：2004-05-27

  In one aspect, the present invention is directed to a one pot method of preparing intermediates of Formula V, which are useful in making inhibitors of phosphodiesterase-4: 1 The present invention is also directed to a method of preparing phosphodiesterase inhibitors comprising the Formula 2

  在一个方面，本发明涉及一种制备Formula V中间体的一锅法，该中间体在制备磷酸二酯酶-4抑制剂时非常有用： 另外，本发明还涉及一种制备磷酸二酯酶抑制剂的方法，包括Formula 2。
• US7312334B2
  申请人：——

  公开号：US7312334B2

  公开（公告）日：2007-12-25
• [EN] METHOD OF PREPARING INHIBITORS OF PHOSPHODIESTERASE-4<br/>[FR] PROCEDE DE PREPARATION D'INHIBITEURS DE PHOSPHODIESTERASE-4
  申请人：MERCK & CO INC

  公开号：WO2004048377A2

  公开（公告）日：2004-06-10

  In one aspect, the present invention is directed to a one pot method of preparing intermediates of Formula (V), which are useful in making inhibitors of phosphodiesterase-4. The present invention is also directed to a method of preparing phosphodiesterase inhibitors comprising the Formula (IX, IXa).