methyl (E)-3-<14-(methyl 7-oxopodocarpa-8,11,13-trien-19-oate)>prop2-enoate | 142508-18-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: methyl (E)-3-<14-(methyl 7-oxopodocarpa-8,11,13-trien-19-oate)>prop2-enoate
• CAS: 142508-18-7
• 化学式: C₂₂H₂₆O₅
• 分子量: 370.445
• InChiKey: RJMHYFSQQIWBSR-GNYRNVKSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  27.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  69.67
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  methyl (E)-3-<14-(methyl 7-oxopodocarpa-8,11,13-trien-19-oate)>prop2-enoate 反应 72.0h， 以35%的产率得到methyl (Z)-3-<14-(methyl 7-oxopodocarpa-8,11,13-trien-19-oate)>prop-2-enoate
  参考文献：
  名称：

  Reactions with alkenes of η2-7-oxotetracarbonylmanganese complexes derived from diterpenoids

  摘要：

  A number of activated 7-oxotetracarbonylmanganese(I) complexes derived from podocarpic acid (1) and from dehydroabietic acid have been coupled with alkenes to give C(14) functionalised derivatives in high yields. Some coupling reactions resulted in cyclization to C(7), forming 4H-acephenanthrylene derivatives in moderate yields. Several modes of activating these manganese complexes towards coupling reactions were investigated; these included oxidative decarbonylation at room temperature, thermal promotion, and palladium-mediation.

  DOI：

  10.1016/0022-328x(92)83318-c
• 作为产物：
  描述：

  丙烯酸甲酯（MA） 、 alkaline earth salt of/the/ methylsulfuric acid 在 lithium chloride 、 palladium dichloride 作用下， 以 甲醇 为溶剂， 反应 23.0h， 以11%的产率得到methyl 7-oxopodocarpa-8,11,13-trien-19-oate
  参考文献：
  名称：

  Reactions with alkenes of η2-7-oxotetracarbonylmanganese complexes derived from diterpenoids

  摘要：

  A number of activated 7-oxotetracarbonylmanganese(I) complexes derived from podocarpic acid (1) and from dehydroabietic acid have been coupled with alkenes to give C(14) functionalised derivatives in high yields. Some coupling reactions resulted in cyclization to C(7), forming 4H-acephenanthrylene derivatives in moderate yields. Several modes of activating these manganese complexes towards coupling reactions were investigated; these included oxidative decarbonylation at room temperature, thermal promotion, and palladium-mediation.

  DOI：

  10.1016/0022-328x(92)83318-c