diethoxymethyl(trimethyl)stannane | 672298-66-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: diethoxymethyl(trimethyl)stannane
• CAS: 672298-66-7
• 化学式: C₈H₂₀O₂Sn
• 分子量: 266.956
• InChiKey: LFHUEKRYINEMAY-UHFFFAOYSA-N

物化性质

• 沸点：
  200.4±50.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.26
• 重原子数：
  11.0
• 可旋转键数：
  5.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.46
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  diethoxymethyl(trimethyl)stannane 、 Boc-D-苯甘氨醇 在 camphor-10-sulfonic acid 作用下， 以 环己烷 为溶剂， 生成 tert-butyl (2S,4R)-4-phenyl-2-trimethylstannyl-1,3-oxazolidine-3-carboxylate 、 tert-butyl (2S,4R)-4-phenyl-2-trimethylstannyl-1,3-oxazolidine-3-carboxylate
  参考文献：
  名称：

  N-Boc-2-stannyloxazolidines Derived from (R)-Phenylgly- cinol: Preparation, Transmetalation, and Use as Precursors  of Enantioenriched (α-Aminoalkyl)triorganostannanes

  摘要：

  Upon transmetalation with n-butyllithium (THF, -78 degreesC, 30 min), 2-(triorganostannyl)oxazolidines afforded the corresponding 2-lithiooxazolidine species, which were proved to be configurationally stable under these experimental conditions. When 2-(triorganostannyl)oxazolidines were involved in reactions with organocuprates promoted by boron trifluoride, the oxazolidine ring was opened to give stereoselectively the enantioenriched N-Boc (alpha-aminoalkyl)triorganostannanes whose absolute configuration of the major isomer was determined by an X-ray analysis.

  DOI：

  10.1021/om034267t