No._1:_CN_101225074 A | 1044857-68-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: No._1:_CN_101225074 A
• 英文别名: 2-[2-Chloro-4-(4-chlorophenoxy)phenyl]-4-phenyl-1-(1,2,4-triazol-1-yl)but-3-en-2-ol
• CAS: 1044857-68-2
• 化学式: C₂₄H₁₉Cl₂N₃O₂
• 分子量: 452.34
• InChiKey: DESHCFCTPNSAMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  60.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1H-1,2,4-三唑 、 2-(2-chloro-4-(4-chlorophenoxy)phenyl)-2-styryloxirane 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以68.9%的产率得到No._1:_CN_101225074 A
  参考文献：
  名称：

  Synthesis and Fungicidal Evaluation of 2-Arylphenyl Ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol Derivatives

  摘要：

  A series of novel 2-arylphenyl ether-3-(1H-1,2,4-triazol-1-yl)propan-2-ol derivatives were designed and synthesized as candidate fungicides. The new compounds were identified by H-1 NMR spectroscopy and element analysis. Their antifungal activities were evaluated. They exhibited excellent antifungal activities against five common pathogens in comparison with the commercial fungicides tebuconazole and difenoconazole. The antifungal activities of three new triazole alcohol compounds were compared with those of tebuconazole and difenoconazole at a concentration of 1 mu g/mL.

  DOI：

  10.1021/jf900222s

文献信息

• [EN] FUNGICIDAL SUBSTITUTED 1-{2-[2-HALO-4-(4-HALOGEN-PHENOXY)-PHENYL ]-2-ALKOXY-2-CYCLYL-ETHYL}-1H [1,2,4]TRIAZOLE COMPOUNDS<br/>[FR] COMPOSÉS DE 1-{2-[2-HALOGÉNO-4-(4-HALOGÉNO-PHÉNOXY)-PHÉNYL]-2-ALCOXY-2-CYCLYL-ÉTHYL}-1H-[1,2,4]TRIAZOLE SUBSTITUÉS FONGICIDES
  申请人：BASF SE

  公开号：WO2013024080A1

  公开（公告）日：2013-02-21

  The present invention relates to substituted 1 -2-[2-halo-4-(4-halogen-phenoxy)- phenyl]-2-alkoxy-2-cyclyl-ethyl}-1 H-[1,2,4]triazole compounds of formula I as defined in the description, and the N-oxides, and salts thereof, processes and intermediates for preparing these compounds and also to compositions comprising at least one such compound.. The invention also relates to the use of such compounds and compositions for combating harmful fungi and seed coated with at least one such compound.

  本发明涉及以下化学式I所定义的取代的1-2-[2-卤代-4-(4-卤代苯氧基)苯基]-2-烷氧基-2-环丙基乙基}-1H-[1,2,4]三唑化合物及其N-氧化物和盐，以及制备这些化合物的过程和中间体，还涉及至少包含一种这样的化合物的组合物。本发明还涉及使用这样的化合物和组合物来对抗有害真菌和至少包含一种这样的化合物的种子包衣。
• Fungicidal substituted 1--1H-[1,2,4]triazole compounds
  申请人：Dietz Jochen

  公开号：US20140187422A1

  公开（公告）日：2014-07-03

  The present invention relates to substituted 1-2-[2-halo-4-(4-halogen-phenoxy)-phenyl]-2-alkoxy-2-cyclyl-ethyl}-1H-[1,2,4]triazole compounds of formula I as defined in the description, and the N-oxides, and salts thereof, processes and intermediates for preparing these compounds and also to compositions comprising at least one such compound. The invention also relates to the use of such compounds and compositions for combating harmful fungi and seed coated with at least one such compound.

  本发明涉及一种代替的1-2-[2-卤代-4-(4-卤代苯氧基)苯基]-2-烷氧基-2-环烷基乙基}-1H-[1,2,4]三唑化合物，其化学式如描述中所定义，以及其N-氧化物和盐，制备这些化合物的过程和中间体，以及包含至少一种这样的化合物的组合物。本发明还涉及使用这样的化合物和组合物来对抗有害真菌和至少包含一种这样的化合物的种子涂层。
• FUNGICIDAL SUBSTITUTED 1-{2-[2-HALO-4-(4-HALOGEN-PHENOXY)-PHENYL]-2-ALKOXY-2-CYCLYL-ETHYL}-1H [1,2,4]TRIAZOLE COMPOUNDS
  申请人：BASF SE

  公开号：EP2744795B1

  公开（公告）日：2015-12-30
• AMINOPYRIMIDINE INHIBITORS OF TYROSINE KINASE
  申请人：Auspex Pharmaceuticals, Inc.

  公开号：US20140227260A1

  公开（公告）日：2014-08-14

  The present invention relates to new aminopyrimidine inhibitors of tyrosine kinase activity, pharmaceutical compositions thereof, and methods of use thereof.