1,2,3,4,6,7,8,8a-Octahydro-1,6-dioxo-naphthalin | 42576-97-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,2,3,4,6,7,8,8a-Octahydro-1,6-dioxo-naphthalin
• 英文别名: 1,6-Dioxo-1,2,3,4,6,7,8,8a-octahydro-naphthalin；5(10)-Octalin-1,6-dion；3,4,8,8a-tetrahydro-2H,7H-naphthalene-1,6-dione；3,4,8,8a-Tetrahydro-2H,7H-naphthalin-1,6-dion；2,3,4,7,8,8a-Hexahydronaphthalene-1,6-dione
• CAS: 42576-97-6
• 化学式: C₁₀H₁₂O₂
• 分子量: 164.204
• InChiKey: HMJJEFPBARGSAT-UHFFFAOYSA-N

物化性质

• 熔点：
  44-46 °C(Solv: ethyl ether (60-29-7))
• 沸点：
  334.8±31.0 °C(Predicted)
• 密度：
  1.13±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-甲氧基-1-萘满酮 生成 1,2,3,4,6,7,8,8a-Octahydro-1,6-dioxo-naphthalin
  参考文献：
  名称：

  RAO C.;SESHU S.;RAJAGOPALAN K.;WAMINATHAN S. S., INDIAN J. CHEM., 1982, B21, NO 8, 753-54

  摘要：

  DOI：

文献信息

• Base Stable Ionic Liquids
  申请人：Earle Martyn J.

  公开号：US20090216015A1

  公开（公告）日：2009-08-27

  The present invention relates to novel base stable ionic liquids and uses thereof as solvents in chemical reactions, especially base catalysed chemical reactions and reactions comprising the use of strong basis.

  本发明涉及新型稳定碱基的离子液体及其在化学反应中的用途，特别是在碱催化化学反应和涉及强碱使用的反应中作为溶剂的用途。
• INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-ALPHA MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS
  申请人：Palladino Michael A.

  公开号：US20110160309A1

  公开（公告）日：2011-06-30

  Described herein are chemical compounds and pharmaceutical compositions, including novel chemical compounds and pharmaceutical compositions thereof, useful in the treatment of various diseases and disease states. Also described are methods of synthesizing natural products and novel, structurally-related chemical compounds. More particularly, disclosed are new analogs of and processes for the preparation of compounds and pharmaceutical compositions thereof useful in the treatment of, for example, inflammation, cancer, multiple myeloma, cachexia, cardiovascular disease, anti-infectious, diabetes, otitis media, sinusitis and transplant rejection.

  本文描述了化学化合物和药物组合物，包括新型化学化合物和药物组合物，用于治疗各种疾病和疾病状态。还描述了合成天然产物和新的结构相关化学化合物的方法。更具体地，披露了用于治疗炎症、癌症、多发性骨髓瘤、消瘦、心血管疾病、抗感染、糖尿病、中耳炎、鼻窦炎和移植排斥等疾病的化合物和药物组合物的新类似物和制备方法。
• IONIC LIQUIDS WITH A CATION COMPRISING A BASIC MOIETY
  申请人：The Queen's University of Belfast

  公开号：EP2286915A2

  公开（公告）日：2011-02-23

  Use of ionic liquids as solvents in base-catalysed chemical reactions wherein the ionic liquid is composed of at least one species of cation and at least one species of anion, characterised in that a cation of the ionic liquid comprises a positively charge moiety and a basic moiety, and further wherein such ionic liquids may be used as promoters or catalysts for the chemical reactions.

  在碱催化的化学反应中使用离子液体作为溶剂，其中离子液体由至少一种阳离子和至少一种阴离子组成，其特征在于离子液体的阳离子包括一个带正电荷的分子和一个带碱的分子，而且这种离子液体可用作化学反应的促进剂或催化剂。
• Base stable ionic liquids
  申请人：The Queen's University of Belfast

  公开号：EP2319621A2

  公开（公告）日：2011-05-11

  The present invention relates to novel base stable ionic liquids and uses thereof as solvents in chemical reactions, especially base catalysed chemical reactions and reactions comprising the use of strong basis.

  本发明涉及新型碱稳定离子液体及其在化学反应中作为溶剂的用途，特别是碱催化的化学反应和包括使用强碱的反应。
• NOVEL INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-ALPHA MODULATORS, SYNTHESES OF SAID MODULATORS AND METHODS OF USING SAID MODULATORS
  申请人：Nereus Pharmaceuticals, Inc.

  公开号：EP1178952B1

  公开（公告）日：2007-08-22