trimethyl-(2-(2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl)-cyclohexylidene-methoxy)-silane | 908274-93-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: trimethyl-(2-(2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl)-cyclohexylidene-methoxy)-silane
• CAS: 908274-93-1
• 化学式: C₁₆H₃₀O₃Si
• 分子量: 298.498
• InChiKey: WEYKGZOKUDOPMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.46
• 重原子数：
  20.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  27.69
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  trimethyl-(2-(2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl)-cyclohexylidene-methoxy)-silane 在 四丁基氟化铵 、 sodium hydride 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 5.5h， 生成
  参考文献：
  名称：

  Tandem Intramolecular Michael-Aldol Reaction as a Tool for the Construction of the C-Ring of Hexacyclinic Acid

  摘要：

  The tandem intramolecular Michael-aldol reaction was studied as a tool for the construction of the C-ring of hexacyclinic acid. By changing the reaction conditions it was possible to selectively obtain either the kinetic or the thermodynamic product. Retro-aldol reaction and subsequent epimerization provides four individual cyclopentane derivatives that can be incorporated as building blocks in natural product syntheses.

  DOI：

  10.1021/ol061096q
• 作为产物：
  描述：

  2-(2-溴乙基)-2-甲基-1,3-二恶茂烷 在 copper(I) bromide dimethylsulfide complex 、 magnesium 作用下， 以 四氢呋喃 、 六甲基磷酰三胺 为溶剂， 反应 7.0h， 生成 trimethyl-(2-(2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl)-cyclohexylidene-methoxy)-silane
  参考文献：
  名称：

  Tandem Intramolecular Michael-Aldol Reaction as a Tool for the Construction of the C-Ring of Hexacyclinic Acid

  摘要：

  The tandem intramolecular Michael-aldol reaction was studied as a tool for the construction of the C-ring of hexacyclinic acid. By changing the reaction conditions it was possible to selectively obtain either the kinetic or the thermodynamic product. Retro-aldol reaction and subsequent epimerization provides four individual cyclopentane derivatives that can be incorporated as building blocks in natural product syntheses.

  DOI：

  10.1021/ol061096q