| 1193536-69-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1193536-69-4
• 化学式: C₄₅H₇₅NO₃₅
• 分子量: 1190.08
• InChiKey: CPWPEPURHUWHRV-YMVLNWLMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -16.05
• 重原子数：
  81.0
• 可旋转键数：
  21.0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  577.08
• 氢给体数：
  23.0
• 氢受体数：
  36.0

反应信息

• 作为反应物：
  描述：

  、 乙酸酐 以 甲醇 为溶剂， 以8.75 g的产率得到N-maltoheptaosyl-3-acetamido-1-propyne
  参考文献：
  名称：

  Thermoresponsive Vesicular Morphologies Obtained by Self-Assemblies of Hybrid Oligosaccharide-block-poly(N-isopropylacrylamide) Copolymer Systems

  摘要：

  This work discusses the self-assembly properties of thermoresponsive hybrid oligosaccharide-block-poly(N-isopropylacrylamide) copolymer systems: maltoheptase-block-poly(N-isopropylacrylamide) (Mal(7)-b-PNIPAM(n)) copolymers. Those systems at different molar masses and volume fractions were synthesized Using Cu(I)-catalyzed 1,3-dipolar azide/alkyne cycloaddition, so-called "click" chemistry, between an alkynyl-functionalized maltoheptaose (I) and poly(N-isopropylacrylamide) having a terminal azido group (N-3-PNIPAM(n)) prepared by atom transfer radical polymerization (ATRP). While the cloud point (T-cp) of the N-3-PNIPAM(n) ranged from 36.4 to 51.5 degrees C depending on the degree of polymerization, those obtained of the diblock copolymers ranged from 39.4 to 73.9 degrees C. The self-assembly of such systems is favored due to the hydrophobicity of the PNIPAM in water above the T-cp. While the N-3-PNIPAM(n) present polydisperse globular shape with a mean diameter of 500 nm, well-defined vesicular morphologies with an approximate diameter of 300 nm are obtained in diblock copolymer systems. These results were obtained and confirmed using static and dynamic light scattering as well as imaging techniques such as transmission electron microscope experiments.

  DOI：

  10.1021/la902743y
• 作为产物：
  描述：

  炔丙胺 、 麦芽七糖 反应 72.0h， 生成
  参考文献：
  名称：

  Sweet Block Copolymer Nanoparticles: Preparation and Self-Assembly of Fully Oligosaccharide-Based Amphiphile

  摘要：

  The preparation of biocompatible nanocarriers that have potential applications in the cosmetic and health industries is highly desired. The self-assembly of amphiphilic block copolymers displaying biosourced polysaccharides at the surface is one of the most promising approaches. In the continuity of our works related to the preparation of "hybrid" amphiphilic oligosaccharide-based block copolymers, we present here the design of a new generation of self-assembled nanoparticles composed entirely of oligosaccharide-based amphiphilic block co-oligomers (BCO). These systems are defined by a covalent linkage of the two saccharidic blocks through their reducing end units, resulting in a sweet "head-to-head" connection. As an example, we have prepared and studied a BCO in which the hydrophilic part is composed of a free maltoheptaosyl derivative clicked to a hydrophobic part composed of a peracetylated maltoheptaosyl derivative. This amphiphilic BCO self-assembles to form spherical micelles in water with an average diameter of 30 nm. The efficient enzymatic hydrolysis of the maltoheptaose that constitutes the shell of the micelles was followed by light scattering and colorimetric methods.

  DOI：

  10.1021/bm3000138