5-Chlor-7-methyl-8-hydroxy-chinolin | 103027-55-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 5-Chlor-7-methyl-8-hydroxy-chinolin
• 英文别名: 5-chloro-7-methyl-quinolin-8-ol；5-Chloro-7-methylquinolin-8-ol
• CAS: 103027-55-0
• 化学式: C₁₀H₈ClNO
• 分子量: 193.633
• InChiKey: WERASJHQBKNNBO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] ZINC IONOPHORES AND USES THEREOF<br/>[FR] IONOPHORES DE ZINC ET UTILISATIONS ASSOCIÉES
  申请人：UNIV QUEENSLAND

  公开号：WO2019071325A1

  公开（公告）日：2019-04-18

  This invention relates to the use of zinc(II) salts in combination with a zinc ionophore to resensitize a previously resistant pathogenic bacteria to an antibiotic. Methods of restoring the sensitivity of a resistant pathogenic bacterium to an antibiotic comprising administering a zinc ionophore in combination with a zinc(II) salt and methods of treating a bacterial infection comprising administering a zinc ionophore in combination with a zinc (II) salt concurrently and/or sequentially with administration of a therapeutically effective amount of an antibiotic is also described.

  这项发明涉及使用锌(II)盐与锌离子载体结合，使先前对抗生素耐药的病原细菌重新对抗生素产生敏感性。还描述了恢复对抗生素耐药病原细菌敏感性的方法，包括同时或顺序地与治疗有效量的抗生素一起给予锌离子载体和锌(II)盐，以及治疗细菌感染的方法。
• COMPOSITION FOR HARDENING SOFT TISSUE
  申请人：THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

  公开号：US20190315770A1

  公开（公告）日：2019-10-17

  The present invention relates to various compounds capable of temporarily hardening soft tissue for surgical suturing of the soft tissue. The compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, thereby improving the suturing efficiency during suturing of the soft tissue, thereby preventing aftereffects or the like from occurring due to insufficient anastomosis. In addition, the compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, particularly pancreas, thereby increasing the suturing efficiency during pancreaticoduodenectomy and effectively preventing pancreatic leakage.

  本发明涉及各种能够暂时硬化软组织以进行软组织缝合的化合物。根据本发明的化合物可以暂时增加软组织的硬度或张力，从而在缝合软组织时提高缝合效率，防止由于吻合不足而产生的后遗症或类似问题的发生。此外，根据本发明的化合物可以暂时增加软组织，特别是胰腺的硬度或张力，从而在胰十二指肠切除术期间提高缝合效率并有效预防胰液漏出。
• METHOD FOR THE DIAGNOSIS, PROGNOSIS AND TREATMENT OF LUNG CANCER METASTASIS
  申请人：Fundació Institut de Recerca Biomèdica IRB (Barcelona)

  公开号：EP3467124A1

  公开（公告）日：2019-04-10

  The present invention relates to a method for the diagnosis or the prognosis of metastasis in lung cancer which comprises determining if the c-MAF gene is amplified in a primary tumor sample. Likewise, the invention also relates to a method for the diagnosis or the prognosis of metastasis in lung cancer, as well as to a method for determining the tendency to develop bone metastasis with respect to metastasis in other organs, which comprise determining the c-MAF gene expression level. Finally, the invention relates to the use of a c-MAF inhibitor as therapeutic target for treating the lung cancer.

  本发明涉及肺癌转移的诊断或预后方法，该方法包括确定原发肿瘤样本中 c-MAF 基因是否扩增。同样，本发明还涉及一种诊断或预后肺癌转移的方法，以及一种确定相对于其他器官转移的骨转移倾向的方法，该方法包括确定 c-MAF 基因的表达水平。最后，本发明涉及使用 c-MAF 抑制剂作为治疗肺癌的靶点。
• Composition for hardening soft tissue
  申请人：THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

  公开号：US10745417B2

  公开（公告）日：2020-08-18

  The present invention relates to various compounds capable of temporarily hardening soft tissue for surgical suturing of the soft tissue. The compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, thereby improving the suturing efficiency during suturing of the soft tissue, thereby preventing aftereffects or the like from occurring due to insufficient anastomosis. In addition, the compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, particularly pancreas, thereby increasing the suturing efficiency during pancreaticoduodenectomy and effectively preventing pancreatic leakage.

  本发明涉及能够暂时硬化软组织的各种化合物，用于软组织的外科缝合。根据本发明的化合物可以暂时增加软组织的硬度或张力，从而在缝合软组织时提高缝合效率，防止因吻合不足而产生后遗症等。此外，根据本发明的化合物可以暂时增加软组织尤其是胰腺的硬度或张力，从而提高胰十二指肠切除术的缝合效率，有效防止胰腺渗漏。
• COMPOSES INHIBITEURS DE PSEUDOMONAS AERUGINOSA
  申请人：Centre National de la Recherche Scientifique (CNRS)

  公开号：EP3322421B1

  公开（公告）日：2020-06-10