3-oxo-nonanal | 214782-59-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-oxo-nonanal
• 英文别名: Nonane-1,3-dione；3-oxononanal
• CAS: 214782-59-9
• 化学式: C₉H₁₆O₂
• 分子量: 156.225
• InChiKey: IOOWZEYQYCHTDP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-oxo-nonanal 、 4-庚氧基苯胺 以 1,4-二氧六环 、 乙醚 、 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Kozyreva, E. G.; Bolotin, B. M.; Kokin, V. N., Russian Journal of Organic Chemistry, 1994, vol. 30, # 7.1, p. 1082 - 1087

  摘要：

  DOI：
• 作为产物：
  描述：

  仲辛酮 、 甲酸乙酯 在 sodium 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 生成 3-oxo-nonanal
  参考文献：
  名称：

  Kozyreva, E. G.; Bolotin, B. M.; Kokin, V. N., Russian Journal of Organic Chemistry, 1994, vol. 30, # 7.1, p. 1082 - 1087

  摘要：

  DOI：

文献信息

• [EN] PHTHALAZINONE DERIVATIVES<br/>[FR] DERIVES DE PHTHALAZINONE
  申请人：KUDOS PHARM LTD

  公开号：WO2003093261A1

  公开（公告）日：2003-11-13

  A compound of formula (I); or an isomer, salt, solvate, chemically protected form, or prodrug thereof, wherein A and B together represent an optionally substituted, fused aromatic ring; RL is a C5-7 aryl group substituted in the meta position by the group R2, and optionally further substituted; wherein R2 is selected from formula (II) and formula (III); and its use as a pharmaceutical, in particular for the treatment of diseases ameliorated by inhibiting the activity of PARP.

  一种具有化学式（I）的化合物；或其异构体、盐、溶剂合物、化学保护形式、或前药，其中A和B共同代表一个可选择取代的融合芳香环；RL是一个C5-7芳基基团，在邻位由基团R2取代，并可选择进一步取代；其中R2选自化学式（II）和化学式（III）；以及其作为药物的用途，特别用于治疗通过抑制PARP活性改善的疾病。
• [EN] EPIDITHIODIKETOPIPERAZINE COMPOUNDS, COMPOSITIONS, AND METHODS<br/>[FR] COMPOSÉS ÉPIDITHIODICÉTOPIPÉRAZINES, COMPOSITIONS ET PROCÉDÉS
  申请人：GLOBAVIR BIOSCIENCES INC

  公开号：WO2015095821A1

  公开（公告）日：2015-06-25

  Epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of their synthesis, as part of treating, inhibiting and reducing transcription and translation of hypoxia inducible genes are described. In another aspect, the present disclosure describes a method for interfering with hypoxia-induced transcriptional pathway in a cell comprising: contacting the cell with at least one compound disclosed herein. In another aspect, the present disclosure describes a method for treating breast cancer, a solid cancer, a blood cancer, a subject suffering from carcinoma in need of said treatment, and renal cell carcinoma (RCC), comprising: administering to the subject an effective amount of at least one compound disclosed herein. In some embodiments of the methods described herein, the method further comprises administering an additional anti-cancer and/or cytotoxic agent.

  描述了Epidithiodiketopiperazine化合物、基于该化合物的药物组合物及其合成方法，作为治疗、抑制和减少低氧诱导基因的转录和翻译的一部分。在另一个方面，本公开说明描述了一种干扰细胞中低氧诱导转录途径的方法，包括：将细胞与至少一种本公开披露的化合物接触。在另一个方面，本公开说明描述了一种治疗乳腺癌、实体癌、血液癌、需要接受所述治疗的患有癌症的受试者以及肾细胞癌（RCC）的方法，包括：向受试者施用至少一种本公开披露的化合物的有效量。在所述方法的一些实施方式中，该方法还包括施用额外的抗癌和/或细胞毒药剂。
• DERIVATIVES OF N-[(1,5-DIPHENYL-1H-PYRAZOL-3-YL)METHYL] SULFONAMIDE, THEIR PREPARATION AND THEIR APPLICATION IN THERAPEUTICS
  申请人：Barth Francis

  公开号：US20080070962A1

  公开（公告）日：2008-03-20

  The present invention relates to compounds corresponding to the formula (I): In which R 1 , R 2 , R 3 , R 4 and R 5 are as described herein. The invention also relates to the method of preparation of said compounds and their application in therapeutics.

  本发明涉及与式(I)相对应的化合物：其中R1、R2、R3、R4和R5如本文所述。该发明还涉及所述化合物的制备方法及其在治疗学中的应用。
• Apoptosis inducer and method of screening for a substance inhibiting acylated homoserine lactone
  申请人：Nomura, Nobuhiko

  公开号：EP1442742A1

  公开（公告）日：2004-08-04

  The present invention relates to an Akt inhibitor comprising a compound represented by formula I: [wherein R is C4-30 linear or branched acyl, which may be substituted.] The present invention further relates to a method of screening for a substance inhibiting acylated homoserine lactone by culturing animal cells with a test substance in the presence of acylated homoserine lactone represented by the above formula I, and then detecting inhibition of Akt activity or inhibition of the survival signalling pathway in which Akt is involved in the cells.

  本发明涉及一种 Akt 抑制剂，包括由式 I 所代表的化合物： [其中R为C4-30直链或支链酰基，可被取代。] 本发明进一步涉及一种筛选抑制酰化高丝氨酸内酯的物质的方法，该方法是在有上述式I代表的酰化高丝氨酸内酯存在的情况下，用试验物质培养动物细胞，然后检测细胞中Akt活性的抑制情况或Akt参与的生存信号通路的抑制情况。
• PESTICIDAL 1-(4-PHENOXYPHENYL)-3-BENZOYL UREA COMPOUNDS AND PROCESS FOR PREPARATION
  申请人：UNION CARBIDE CORPORATION

  公开号：EP0215841A1

  公开（公告）日：1987-04-01