4-(6-甲氧基咪唑并[1,2-a]吡啶-2-基)苯甲醛 | 118000-71-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 4-(6-甲氧基咪唑并[1,2-a]吡啶-2-基)苯甲醛
• 英文名称: Benzaldehyde,4-(6-methoxyimidazo[1,2-a]pyridin-2-yl)-
• 英文别名: 4-(6-methoxyimidazo[1,2-a]pyridin-2-yl)benzaldehyde
• CAS: 118000-71-8
• 化学式: C₁₅H₁₂N₂O₂
• 分子量: 252.272
• InChiKey: YLZHNURHOSMPLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(4-溴苯基)-6-甲氧基咪唑并[1,2-a]吡啶 在 二异丁基氢化铝 作用下， 以 正己烷 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 25.0h， 生成 4-(6-甲氧基咪唑并[1,2-a]吡啶-2-基)苯甲醛
  参考文献：
  名称：

  2-芳基和2-芳氧基甲基咪唑并[1,2- a ]吡啶的制备及相关化合物

  摘要：

  一系列取代的2-芳基咪唑并[1,2-α]吡啶已被制备，其中多种取代基被引入在苯环的4'位和在3，5的，6或7位杂环。大多数实例在4'-位具有乙酰氨基，溴，氰基或甲酰基取代基。还已经制备了类似的咪唑并[ 2，1- b ]噻唑和咪唑并[1,2- a ]嘧啶。制备了由咪唑的4'-甲酰基苯氧基甲基衍生物，吡啶，噻唑，苯并咪唑和环取代的咪唑并[1,2- a ]吡啶的三个位置异构体组成的另一系列化合物。还制备了咪唑和咪唑并[1,2- a ]吡啶的2-（4'-甲酰基苯基乙烯基）衍生物。

  DOI：

  10.1002/jhet.5570250119

文献信息

• SUNDBERG, RICHARD J.;DAHLHAUSEN, D. J.;MANIKUMAR, G.;MAVUNKEL, B.;BISWAS,+, J. HETEROCYCL. CHEM., 25,(1988) N 1, 129-137
  作者：SUNDBERG, RICHARD J.、DAHLHAUSEN, D. J.、MANIKUMAR, G.、MAVUNKEL, B.、BISWAS,+

  DOI：——

  日期：——
• PROCEDE DE COLORATION UTILISANT UN PRECURSEUR DE COLORATION CAPILLAIRE ISSU D'IRIDOIDE, COMPOSITION, PRECURSEUR ET DISPOSITIF LE COMPRENANT
  申请人：L'OREAL

  公开号：EP2978767B1

  公开（公告）日：2018-10-03
• [EN] DYE COMPOSITION COMPRISING A GLYCOSYL IRIDOID COMPOUND AND A PARTICULAR ALDEHYDE OR IMINE, DYEING PROCESS AND DEVICES THEREFOR<br/>[FR] COMPOSITION DE COLORANT COMPRENANT UN COMPOSÉ IRIDOÏDE GLYCOSYLIQUE ET UN ALDÉHYDE PARTICULIER OU UNE IMINE PARTICULIÈRE, PROCÉDÉ DE COLORATION ET DISPOSITIFS S'Y RAPPORTANT
  申请人：OREAL

  公开号：WO2013045704A2

  公开（公告）日：2013-04-04

  The present invention relates to a composition for dyeing human keratin fibres, comprising, in a cosmetically acceptable medium: * a compound of the iridoid family of formula (I) below, or a plant extract comprising the same: in which R1: hydrogen, methyl, hydroxymethyl, aldehyde; -CO2R4 in which R4: hydrogen, C1-C2 alkyl; sugar; R2: a hydrogen atom, a hydroxyl radical, sugar radical; R3: hydrogen, hydroxyl, alkyloxy; R: sugar radical (aldose or derivative); integer ranging from 1 to 5; the compound(s) of formula (I) having optionally undergone a preliminary step consisting in replacing the radical R with a hydrogen atom, performed using an enzyme; ** at least one aldehyde or imine compound of formulae (i) and (ii), and also oxidized oligo- or polysaccharide comprising at least one aldehyde or imine function: with n equal to 0 or 1; X: O, NR'1; A: COOH, optionally substituted aryl, cationic or non-cationic, saturated or unsaturated 5- or 6-membered heterocycle, comprising one or two heteroatoms, optionally substituted, alkyl, alkenyl; A2 divalent alkylene; the compounds possibly being, in the case of aldehydes, in acetal or hemiacetal form. The invention also relates to a process using such a composition, and also to multi-compartment devices.
• [EN] DYE COMPOSITION COMPRISING A NON-GLYCOSYL IRIDOID COMPOUND AND A PARTICULAR ALDEHYDE OR IMINE, DYEING PROCESS AND DEVICE THEREFOR<br/>[FR] COMPOSITION DE COLORANT COMPRENANT UN COMPOSÉ IRIDOÏDE NON GLYCOSYLÉ ET UN ALDÉHYDE OU UNE IMINE PARTICULIER, PROCÉDÉ DE COLORATION ET DISPOSITIF ASSOCIÉ
  申请人：OREAL

  公开号：WO2013045703A1

  公开（公告）日：2013-04-04

  The present invention relates to a composition for dyeing human keratin fibres, comprising, in a cosmetically acceptable medium: a compound of formula (I) and/or of formula (II) below, or a plant extract comprising the same: with R1 : hydrogen, (hydroxy)methyl, aldehyde, -CO2R4 and R4: hydrogen, alkyl, - CH2-glucose; R2: hydrogen, hydroxyl, glucose; R3: hydrogen, hydroxyl, alkyloxy; n ranging from 1 to 5; R5: -C02R'6 and R'6: hydrogen, alkyl, cation; at least one aldehyde or imine compound of formulae (i) and (ii), and also oxidized oligo- or polysaccharide comprising at least one aldehyde or imine function: with n equal to 0 or 1; X: O, NR'-1; A: COOH, optionally substituted aryl, cationic or non-cationic, saturated or unsaturated 5- or 6-membered heterocycle, comprising one or two heteroatoms, optionally substituted, alkyl, alkenyl; A2 divalent alkylene; the compounds possibly being, in the case of aldehydes, in acetal or hemiacetal form. A subject of the invention is also a process using such a composition and a multicompartment device comprising a first compartment containing at least one compound of formula (I) and/or (II) or a plant extract comprising the same, and a second compartment containing at least one compound of formula (i) or (ii), an oxidized oligo- or polysaccharide comprising at least one aldehyde or imine function.
• [EN] DYEING METHOD USING A HAIR-DYEING PRECURSOR OBTAINED FROM IRIDOIDS, COMPOSITION, PRECURSOR AND DEVICE INCLUDING SAME<br/>[FR] PROCEDE DE COLORATION UTILISANT UN PRECURSEUR DE COLORATION CAPILLAIRE ISSU D'IRIDOIDE, COMPOSITION, PRECURSEUR ET DISPOSITIF LE COMPRENANT
  申请人：OREAL

  公开号：WO2014154957A1

  公开（公告）日：2014-10-02

  La présente invention a pour objet un procédé de coloration mettant en oeuvre une composition comprenant au moins un précurseur de coloration issu d'iridoïde(s) non glycosylé(s) de formule (I) et au moins un agent oxydant chimique, une composition comprenant au moins un précurseur de coloration, un dispositif comprenant lesdits précurseurs, les précurseurs de colorations et un procédé de préparation desdits précurseurs. La composition et le procédé de coloration selon l'invention permettent d'obtenir des colorations variées, ne dégradant pas les cheveux, tenaces notamment vis-à-vis des shampooings.