1-[2-hydroxy-2-(4-(methylthiomethoxy)phenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide | 1160707-36-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-[2-hydroxy-2-(4-(methylthiomethoxy)phenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide
• 英文别名: 1-[2-hydroxy-2-[4-(methylsulfanylmethoxy)phenyl]acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide
• CAS: 1160707-36-7
• 化学式: C₂₂H₂₅IN₂O₄S
• 分子量: 540.422
• InChiKey: XZYCAMRKLJHPQQ-UHFFFAOYSA-N

物化性质

• 沸点：
  737.5±60.0 °C(Predicted)
• 密度：
  1.576±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  104
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-[2-hydroxy-2-(4-(methylthiomethoxy)phenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide 在 N-氯代丁二酰亚胺 、 三甲基氯硅烷 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 7.0h， 生成 [1-[4-(Azidomethoxy)phenyl]-2-[4-[(4-iodophenyl)carbamoyl]piperidin-1-yl]-2-oxoethyl] (4-nitrophenyl) carbonate
  参考文献：
  名称：

  RNA-templated molecule release induced protein expression in bacterial cells

  摘要：

  我们开发出了一种根据目标基因序列释放生物活性分子的系统。该释放系统由叠氮甲基还原引发，已成功应用于细菌细胞中由内源 RNA 引发的 IPTG 释放所诱导的蛋白质表达。

  DOI：

  10.1039/c2cc37826d
• 作为产物：
  描述：

  4-羟基扁桃酸 在 potassium tert-butylate 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 、 sodium iodide 作用下， 以 四氢呋喃 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 1-[2-hydroxy-2-(4-(methylthiomethoxy)phenyl)acetyl]-N-(4-iodophenyl)piperidine-4-carboxamide
  参考文献：
  名称：

  RNA-templated molecule release induced protein expression in bacterial cells

  摘要：

  我们开发出了一种根据目标基因序列释放生物活性分子的系统。该释放系统由叠氮甲基还原引发，已成功应用于细菌细胞中由内源 RNA 引发的 IPTG 释放所诱导的蛋白质表达。

  DOI：

  10.1039/c2cc37826d

文献信息

• Nucleic-acid triggered release of molecules
  申请人：Riken

  公开号：EP2105146A1

  公开（公告）日：2009-09-30

  It is an object of the present invention to provide a method for highly selectively releasing a molecule of interest such as an agent at a desired site while suppressing the influence of catabolic enzymes existing in vivo. The present invention provides a method for releasing a molecule of interest, which comprises steps of: hybridizing each of an "electron donor-first nucleic acid probe" molecule formed by binding an electron donor structure to a first nucleic acid probe having a nucleotide sequence complementary to a portion of a target nucleic acid sequence and a "molecule of interest-electron acceptor-second nucleic acid probe" molecule formed by binding an electron acceptor structure having a molecule of interest and an azide group to a second nucleic acid probe that has a nucleotide sequence complementary to said target nucleic acid sequence and differing from that of said first nucleic acid probe, to said target nucleic acid sequence; and allowing said "electron donor-first nucleic acid probe" molecule to act on said "molecule of interest-electron acceptor-second nucleic acid probe" molecule, so as to release said molecule of interest.

  本发明的目的是提供一种高度选择性地在所需位置释放感兴趣的分子（如药物），同时抑制体内存在的分解酶的影响的方法。本发明提供了一种释放感兴趣分子的方法，包括以下步骤：将电子给体结构与具有与目标核酸序列部分互补的第一核酸探针结合形成的“电子给体-第一核酸探针”分子和将具有感兴趣分子和叠氮基团的电子受体结构与具有与目标核酸序列互补且与第一核酸探针不同的第二核酸探针结合形成的“感兴趣分子-电子受体-第二核酸探针”分子与目标核酸序列杂交；并使“电子给体-第一核酸探针”分子作用于“感兴趣分子-电子受体-第二核酸探针”分子，以释放所述感兴趣分子。
• METHOD FOR RELEASING MOLECULE OF INTEREST BASED ON TARGET NUCLEIC ACID SEQUENCE
  申请人：ABE Hiroshi

  公开号：US20090227691A1

  公开（公告）日：2009-09-10

  It is an object of the present invention to provide a method for highly selectively releasing a molecule of interest such as an agent at a desired site while suppressing the influence of catabolic enzymes existing in vivo. The present invention provides a method for releasing a molecule of interest, which comprises steps of: hybridizing each of an “electron donor-first nucleic acid probe” molecule formed by binding an electron donor structure to a first nucleic acid probe having a nucleotide sequence complementary to a portion of a target nucleic acid sequence and a “molecule of interest-electron acceptor-second nucleic acid probe” molecule formed by binding an electron acceptor structure having a molecule of interest and an azide group to a second nucleic acid probe that has a nucleotide sequence complementary to said target nucleic acid sequence and differing from that of said first nucleic acid probe, to said target nucleic acid sequence; and allowing said “electron donor-first nucleic acid probe” molecule to act on said “molecule of interest-electron acceptor-second nucleic acid probe” molecule, so as to release said molecule of interest.