methyl 2-carbomethoxy-8-<(tetrahydro-2H-pyran-2-yl)oxy>-octanoate | 111014-00-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methyl 2-carbomethoxy-8-<(tetrahydro-2H-pyran-2-yl)oxy>-octanoate
• 英文别名: dimethyl 2-[6-(oxan-2-yloxy)hexyl]propanedioate
• CAS: 111014-00-7
• 化学式: C₁₆H₂₈O₆
• 分子量: 316.395
• InChiKey: PMBFEXJYIHOYIC-UHFFFAOYSA-N

物化性质

• 沸点：
  394.2±42.0 °C(Predicted)
• 密度：
  1.07±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.44
• 重原子数：
  22.0
• 可旋转键数：
  10.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  71.06
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  methyl 2-carbomethoxy-8-<(tetrahydro-2H-pyran-2-yl)oxy>-octanoate 在 4-甲基苯磺酸吡啶 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 以85%的产率得到methyl 8-hydroxy-2-(methoxycarbonyl)octanoate
  参考文献：
  名称：

  Design and synthesis of macro-heterocycles structurally related to tirofiban

  摘要：

  Sequences of nine and four steps were designed to yield two tirobifan related macrocycles by SN2 macrocyclization. The cyclic compounds contain the amino acid tyrosine, one insaturation and are either 18- or 20-membered rings. All the reaction conditions are very mild and the overall yields indicate that the results depend a lot on the structure of the targets and on the length of the reaction sequence. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(00)00709-7
• 作为产物：
  描述：

  1,6-己二醇 在 对甲苯磺酸 、 三苯基膦 、 偶氮二甲酸二乙酯 、 碘甲烷 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 生成 methyl 2-carbomethoxy-8-<(tetrahydro-2H-pyran-2-yl)oxy>-octanoate
  参考文献：
  名称：

  Design and synthesis of macro-heterocycles structurally related to tirofiban

  摘要：

  Sequences of nine and four steps were designed to yield two tirobifan related macrocycles by SN2 macrocyclization. The cyclic compounds contain the amino acid tyrosine, one insaturation and are either 18- or 20-membered rings. All the reaction conditions are very mild and the overall yields indicate that the results depend a lot on the structure of the targets and on the length of the reaction sequence. (C) 2000 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(00)00709-7

文献信息

• Brillon, Denis; Deslongchamps, Pierre, Canadian Journal of Chemistry, 1987, vol. 65, p. 43 - 55
  作者：Brillon, Denis、Deslongchamps, Pierre

  DOI：——

  日期：——
• BRILLON D.; DESLONGCHAMPS P., CAN. J. CHEM., 65,(1987) N 1, 43-55
  作者：BRILLON D.、 DESLONGCHAMPS P.

  DOI：——

  日期：——